Evidence map›Paper›PMID 31137681›Full record

ArticleCancers2019

ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer.

Gaurav Pandey, Nicholas Borcherding, Ryan Kolb, Paige Kluz, Wei Li, Sonia Sugg, Jun Zhang, Dazhi A Lai, Weizhou Zhang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gaurav PandeyDepartment of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA. gpandey@wustl.edu.
Nicholas BorcherdingDepartment of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA. nicholas-borcherding@uiowa.edu.
Ryan KolbDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. ryankolb@ufl.edu.
Paige KluzDepartment of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA. paige-kluz@uiowa.edu.
Wei LiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. weili1978@gmail.com.
Sonia SuggDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA. sonia-sugg@uiowa.edu.
Jun ZhangDivision of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USA. jun-zhang-1@uiowa.edu.ORCID 0000-0001-7886-6187
Dazhi A LaiSpeed Biosystems, Gaithersburg, MD 20878, USA. alex.lai@speedbiosystems.com.
Weizhou ZhangDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. zhangw@ufl.edu.ORCID 0000-0002-8236-0346
University of Iowa · USUniversity of Florida · USSPEED BioSystems (United States) · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Obesity, inflammation and breast cancerR01CA200673 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
CD177 suppresses breast-cancer development by inhibiting beta-cateninR01CA203834 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
The role of paracrine WNT5A/RYK in ErbB2-driven tumorigenesisF30CA206255 · NCI · UNIVERSITY OF IOWA · PI BORCHERDING, NICHOLAS · 2017 to 2020
$143k
NCI NIH HHS F30 CA206255NCI NIH HHS R01 CA200673NCI NIH HHS R01 CA203834NIGMS NIH HHS T32 GM007337NIH HHS CA200673NIH HHS CA203834NIH HHS CA206255
6 · The paper itself

Abstract

Among all breast cancer types, basal-like breast cancer (BLBC) represents an aggressive subtype that lacks targeted therapy. We and others have found that receptor tyrosine kinase-like orphan receptor 1 (ROR1) is overexpressed in BLBC and other types of cancer and that ROR1 is significantly correlated with patient prognosis. In addition, using primary patient-derived xenografts (PDXs) and

Indexed as

breast cancercancer therapyFGFR signalingROR1

Identifiers

PMID31137681
PMCPMC6562526
OpenAlexW2945055762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.