ArticleInternational journal of molecular sciences2019
Deep Insight into the Transcriptome of the Single Silk Gland of
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of novaluron exposure on cocooning and transcriptional changes of genes in silk gland of silkworm, Bombyx mori.Scientific reports · 2026Article
- Article
- Regionalization of gene expression and cell types in the silk gland of the pantry mothbioRxiv : the preprint server for biology · 2025Article
- Comprehensive Transcriptomic Analyses of Silk-Associated Genes and Functional Characterization of Key Silk Fibroins inInternational journal of molecular sciences · 2025Article
- Evaluating bio-physicochemical properties of raw powder prepared from whole larvae containing liquid silk of the domestic silkworm.Frontiers in nutrition · 2024Article
- Juvenile hormone regulates silk gene expression by mCellular and molecular life sciences : CMLS · 2023Article
- Comparative Silk Transcriptomics Illuminates Distinctive Impact of Artificial Selection in Silkworm Modern Breeding.Insects · 2022Article
- Horizontal Gene Transfer and Gene Duplication of β-Fructofuranosidase Confer Lepidopteran Insects Metabolic Benefits.Molecular biology and evolution · 2021Article
- Reference Transcriptome Data in SilkwormInsects · 2021Article
- A transcriptome atlas of silkworm silk glands revealed by PacBio single-molecule long-read sequencing.Molecular genetics and genomics : MGG · 2020Article
- SilkDB 3.0: visualizing and exploring multiple levels of data for silkworm.Nucleic acids research · 2020Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The silk gland synthesizes and secretes a large amount of protein and stores liquid silk protein at an extremely high concentration. Interestingly, silk proteins and serine protease inhibitors are orderly arranged in the silk gland lumen and cocoon shells. Silk fiber formation and the spinning mechanism have not been fully elucidated. Therefore, we conducted a comparative transcriptome analysis of seven segments of the single silk gland to characterize internal changes in the silk gland during the 5th instar of mature larvae. In total, 3121 differentially expressed genes were identified in the seven segments. Genes highly expressed in the middle silk gland (MSG) were mainly involved in unsaturated fatty acid biosynthesis, fatty acid metabolism, apoptosis-fly, and lysosome pathways, whereas genes highly expressed in the posterior silk gland (PSG) were mainly involved in ribosome, proteasome, citrate cycle, and glycolysis/gluconeogenesis pathways. Thus, the MSG and PSG differ greatly in energy source use and function. Further, 773 gradually upregulated genes (from PSG to MSG) were involved in energy metabolism, silk protein synthesis, and secretion, suggesting that these genes play an important role in silk fiber formation. Our findings provide insights into the mechanism of silk protein synthesis and transport and silk fiber formation.
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