Evidence map›Paper›PMID 31137515›Full record

ArticleInternational journal of molecular sciences2019

Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways.

Siqi Zhang, Qiaoling Song, Xueting Wang, Zhiqiang Wei, Rilei Yu, Xin Wang, Tao Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Siqi ZhangKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. zhang-siqi@qq.com.
Qiaoling SongKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. sql_simm@163.com.
Xueting WangCenter for High Performance Computing & System simulation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China. joanwang0814@outlook.com.
Zhiqiang WeiCenter for High Performance Computing & System simulation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China. weizhiqiang@ouc.edu.cn.
Rilei YuKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. ryu@ouc.edu.cn.ORCID 0000-0001-6625-2014
Xin WangKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. wx8399@ouc.edu.cn.
Tao JiangKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. jiangtao@ouc.edu.cn.
Qingdao National Laboratory for Marine Science and Technology · CNOcean University of China · CN

Funding

Fundamental Research Funds for the Central Universities No. 201762011 for R.Y.Innovation Project from Qingdao National Laboratory for Marine Science and Technology No.2015ASKJ02Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao) No. 2018SDKJ0403National Laboratory Director Fund QNLM201709National Science and Technology Major Project of China 2018ZX09735-004NSFC-Shandong Joint Fund U1706213 and U1406403
6 · The paper itself

Abstract

c-Met is a transmembrane receptor tyrosine kinase and an important therapeutic target for anticancer drugs. In this study, we designed a small library containing 300 BISAs molecules that consisted of carbohydrates, amino acids, isothiourea, tetramethylthiourea, guanidine and heterocyclic groups and screened c-Met targeting compounds using docking and MM/GBSA. Guided by virtual screening, we synthesised a series of novel compounds and their activity on inhibition of the autophosphorylation of c-Met and its downstream signalling pathway proteins were evaluated. We found a panel of benzisoselenazolones (BISAs) obtained by introducing isothiourea, tetramethylthiourea and heterocyclic groups into the C-ring of Ebselen, including

Indexed as

Signal TransductionAntineoplastic AgentsBinding SitesCell Line, TumorCell ProliferationCyclodextrinsHumansMolecular Docking SimulationProtein BindingProtein Kinase InhibitorsProto-Oncogene Proteins c-metAntineoplastic AgentsbenzoisoselenazoloneCyclodextrinsProtein Kinase InhibitorsProto-Oncogene Proteins c-metbenzoisoselenonec-Met inhibitiondockingmolecular dynamics simulationvirtual screening

Identifiers

PMID31137515
PMCPMC6566228
OpenAlexW2945371288

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.