Evidence map›Paper›PMID 31137015›Full record

ArticleEndocrine connections2019

Alteration of the intestinal flora may participate in the development of Graves' disease: a study conducted among the Han population in southwest China.

Mengxue Yang, Bowen Sun, Jianhui Li, Bo Yang, Jie Xu, Xue Zhou, Jie Yu, Xuan Zhang, Qun Zhang, Shan Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. The microbiota in eosinophilic esophagitis: A systematic review.Journal of gastroenterology and hepatology · 2022
    Pooled it
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  15. Frontiers in cellular and infection microbiology · 2024
    Article
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  17. Significance of Gut Microbiota on Graves' Disease.International journal of general medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengxue YangDepartment of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Bowen SunDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Jianhui LiDepartment of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China.
Bo YangDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Jie XuSchool of Public Health, Zunyi Medical University, Zunyi, China.
Xue ZhouDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Jie YuSchool of Public Health, Zunyi Medical University, Zunyi, China.
Xuan ZhangDepartment of Endocrinology, Zunyi Medical University, Zunyi, China.
Qun ZhangDepartment of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China.
Shan ZhouDepartment of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China.
Xiaohua SunDepartment of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe pathogenesis of Graves' disease (GD) remains unclear. In terms of environmental factors, GD development may be associated with chronic inflammation caused by alteration of the intestinal flora. This study explored the association of intestinal flora alteration with the development of GD among the Han population in southwest China. DESIGN AND

methodsFifteen GD patients at the Affiliated Hospital of Zunyi Medical College between March 2016 and March 2017 were randomly enrolled. Additionally, 15 sex- and age-matched healthy volunteers were selected as the control group during the same period. Fresh stool samples were collected, and bacterial 16S RNA was extracted and amplified for gene sequencing with the Illumina MiSeq platform. The sequencing results were subjected to operational taxonomic unit-based classification, classification verification, alpha diversity analysis, taxonomic composition analysis and partial least squares-discriminant analysis (PLS-DA).

resultsThe diversity indices for the GD group were lower than those for the control group. The GD group showed significantly higher abundances of Firmicutes, Proteobacteria and Actinobacillus and a higher Firmicutes/Bacteroidetes ratio than the control group. PLS-DA suggested the satisfactory classification of the flora between the GD group and the control group. The abundances of the genera Oribacterium, Mogibacterium, Lactobacillus, Aggregatibacter and Mogibacterium were significantly higher in the GD group than in the control group (P < 0.05).

conclusionsThe intestinal flora of GD patients was significantly different from that of the healthy population. Thus, alteration of intestinal flora may be associated with the development of GD.

Indexed as

16S RNAautoimmune thyroid diseaseGraves’ diseasegut microbiota

Identifiers

PMID31137015
PMCPMC6590206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.