ArticleEndocrine connections2019
Diagnostic efficacy of 18F-FDG PET/CT in patients with adrenal incidentaloma.
Article in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Guideline
- Article
- Morpho-Functional and Biochemical Characterization of Adrenal Masses in a Heterogeneous Cancer Population.Cancers · 2025Article
- Washed up: the end of an era for adrenal incidentaloma CT.Insights into imaging · 2025Review
- Adrenal oncocytoma: a rare presentation of a benign 18 F-fluorodeoxyglucose PET avid virilising adrenal tumour.Nuclear medicine communications · 2025Article
- Benign pure androgen-secreting adrenal tumor misdiagnosed as adrenocortical carcinoma onEndocrine · 2025Article
- The value of targeted CXCR4Frontiers in endocrinology · 2025Article
- An interpretableFrontiers in oncology · 2025Article
- Recent Development of CXCR4-Targeted Nuclear Medicine Research in Adrenocortical Tumors.Mini reviews in medicinal chemistry · 2025Review
- Clinical‑imaging‑radiomic nomogram based on unenhanced CT effectively predicts adrenal metastases in patients with lung cancer with small hyperattenuating adrenal incidentalomas.Oncology letters · 2024Article
- Case report: A challenging case of severe Cushing's syndrome in the course of metastatic thymic neuroendocrine carcinoma with a synchronous adrenal tumor.Frontiers in endocrinology · 2024Article
- Adrenal indeterminate nodules: CT-based radiomics analysis of different machine learning models for predicting adrenal metastases in lung cancer patients.Frontiers in oncology · 2024Article
- Small hyperattenuating adrenal nodules in patients with lung cancer: Differentiation of metastases from adenomas on biphasic contrast-enhanced computed tomography.Frontiers in oncology · 2023Article
- Article
- Prevalence and Clinical Significance of Incidental FocalMolecular imaging and radionuclide therapy · 2022Article
- Adrenal Schwannoma in an Elderly Man: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2022Review
- Cushing´s syndrome due to bilateral adrenal cortical disease: Bilateral macronodular adrenal cortical disease and bilateral micronodular adrenal cortical disease.Frontiers in endocrinology · 2022Review
- 18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients.The Journal of clinical endocrinology and metabolism · 2021Article
- Adrenal Vein Cortisol to Metanephrine Ratio for Localizing ACTH-Independent Cortisol-Producing Adenoma: A Case Report.Journal of the Endocrine Society · 2021Article
- The Potential of Steroid Profiling by Mass Spectrometry in the Management of Adrenocortical Carcinoma.Biomedicines · 2020Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of adrenal incidentaloma is still a challenge with respect to determining its functionality (hormone secretion) and malignancy. In this light, we performed 18F-FDG PET/CT scan to assess the SUVmax values in different adrenal masses including Cushing syndrome, pheochromocytoma, primary hyperaldosteronism and non-functional adrenal adenomas.
methodsTotal 109 (73 F, 36 M) patients with adrenal mass (incidentaloma), mean age of 53.3 ± 10.2 years (range, 24-70) were screened by 18F-FDG PET/CT. Data of 18F-FDG PET/CT imaging of the patients were assessed by the same specialist. Adrenal masses were identified according to the calculated standardized uptake values (SUVs). Clinical examination, 24-h urine cortisol, catecholamine metabolites, 1-mg dexamethasone suppression test, aldosterone/renin ratio and serum electrolytes were analyzed.
resultsBased on the clinical and hormonal evaluations, there were 100 patients with non-functional adrenal mass, four with cortisol-secreting, four with pheochromocytomas and one with aldosterone-secreting adenoma. Mean adrenal mass diameter of 109 patients was 2.1 ± 4.3 (range, 1-6.5 cm). The 18F-FDG PET/CT imaging of the patients revealed that lower SUVmax values were found in non-functional adrenal masses (SUVmax 3.2) when compared to the functional adrenal masses including four with cortisol-secreting adenoma (SUVmax 10.1); four with pheochromcytoma (SUVmax 8.7) and one with aldosterone-secreting adenomas (SUVmax 3.30). Cortisol-secreting (Cushing syndrome) adrenal masses showed the highest SUVmax value (10.1), and a cut-off SUVmax of 4.135 was found with an 84.6% sensitivity and 75.6% specificity cortisol-secreting adrenal adenoma.
conclusionsConsistent with the similar studies, non-functional adrenal adenomas typically do not show increased FDG uptake and a certain form of functional adenoma could present various FDG uptake in FDG PET/CT. Especially functional adrenal adenomas (cortisol secreting was the highest) showed increased FDG uptake in comparison to the non-functional adrenal masses. Therefore, setting a specific SUVmax value in the differentiation of malignant adrenal lesion from the benign one is risky and further studies, including a high number of functional adrenal mass are needed.
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