ArticleNeuroImage. Clinical2019
Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW).
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Hippocampal morphometry is altered in infants with congenital heart disease.Brain communications · 2026Article
- Magnetic resonance imaging-based assessment of hippocampal glutamate and morphometric changes in preterm infants at term-equivalent age with low birth weight.Pediatric radiology · 2026Article
- Early life stress impairs hippocampal subfield myelination.Communications biology · 2025Article
- Distinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults.Brain imaging and behavior · 2024Article
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Association of Neonatal Midazolam Exposure With Hippocampal Growth and Working Memory Performance in Children Born Preterm.Neurology · 2023Article
- Reduced Hippocampal Volumes in Children with History of Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia.Children (Basel, Switzerland) · 2023Article
- Hippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhage.Brain structure & function · 2023Article
- Five-to-Fifteen-Parental Perception of Developmental Profile from Age 5 to 8 Years in Children Born Very Preterm.Journal of personalized medicine · 2023Article
- Early life factors and hippocampal functional connectivity in children with overweight/obesity.Pediatric obesity · 2023Article
- Both brain size and biological sex contribute to variation in white matter microstructure in middle-aged healthy adults.Human brain mapping · 2023Article
- FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.Human brain mapping · 2022Review
- Volumetric Brain Loss Correlates With a Relapsing MOGAD Disease Course.Frontiers in neurology · 2022Article
- Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage.Scientific reports · 2021Article
- Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals.Frontiers in neuroscience · 2021Article
- Disruption in Surface-Based Functional Connectivity in the Right Posterior Hippocampal CA3 Subfield: A Probable Neural Basis of Visuospatial Working Memory Impairment in Patients With Right Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Hippocampal subfield volumes are nonspecifically reduced in premature-born adults.Human brain mapping · 2020Article
- Born Too Early and Too Small: Higher Order Cognitive Function and Brain at Risk at Ages 8-16.Frontiers in psychology · 2019Article
- Hippocampal subfield abnormalities and memory functioning in children with fetal alcohol Spectrum disorders.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hippocampus, an essential structure for learning and memory, has a reduced volume in preterm born (gestational age < 37 weeks) individuals with very low birth weight (VLBW: birth weight < 1500 g), which may affect memory function. However, the hippocampus is a complex structure with distinct subfields related to specific memory functions. These subfields are differentially affected by a variety of neuropathological conditions, but it remains unclear how these subfields may be affected by medical complications following preterm birth which may cause aberrant brain development, and the consequences of this on learning and memory function in children with VLBW.
methodsChildren born preterm with VLBW (n = 34) and term-born controls from the Norwegian Mother and Child Cohort Study (MoBa) (n = 104) underwent structural MRI and a neuropsychological assessment of memory function at primary school age. FreeSurfer 6.0 was used to analyze the volumes of hippocampal subfields which were compared between groups, as was memory performance. Correlations between abnormal hippocampal subfields and memory performance were explored in the VLBW group.
resultsAll absolute hippocampal subfield volumes were lower in the children with VLBW compared to MoBa term-born controls, and the volumes of the left and right dentate gyrus and the right subiculum remained significantly lower after correcting for total intracranial volume. The VLBW group had inferior working memory performance and the score on the subtest Spatial Span backwards was positively correlated to the volume of the right dentate gyrus.
conclusionsHippocampal subfield volumes seem to be differently affected by early brain development related to preterm birth. The dentate gyrus appears particularly susceptible to adverse effects of preterm birth. Reduced working memory function among children with VLBW was associated with smaller volume of right dentate gyrus. This finding demonstrates alterations in hippocampal structure-function relationships associated with early brain development related to preterm birth.
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