Observational studyOsteoarthritis and cartilage2019
Osteophyte growth in early thumb carpometacarpal osteoarthritis.
Observational study in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Diagnostic accuracy of history taking, physical examination, and auxiliary examination for thumb osteoarthritis: a systematic review.Annals of medicine · 2025Pooled it
- Small bone replacement leads to greater gait asymmetry, cartilage damage, and osteophyte formation than ligament injury in a porcine wrist model.Osteoarthritis and cartilage open · 2026Article
- Shape predicts osteoarthritis progression in the first carpometacarpal joint.Frontiers in bioengineering and biotechnology · 2026Article
- Association of ligament mechanical properties and articular surface topography with trapeziometacarpal kinematics across osteoarthritis stages.Osteoarthritis and cartilage · 2026Article
- Osteoarthritis Progression, Pain, and Function in Early Carpometacarpal Osteoarthritis: A Six-Year Longitudinal Study.Journal of hand surgery global online · 2025Article
- Three-Dimensional Analysis of Bone Morphology of the Rheumatoid Arthritis Elbow.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Multi-Scale Analysis of Regional Pathology in the Human Trapezium During Osteoarthritis Progression.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Development and Assessment of the Curtis Thumb Carpometacarpal Osteoarthritis Radiographic Classification.Journal of hand surgery global online · 2025Article
- Thumb motion is not the same as first carpometacarpal joint motion.Journal of biomechanics · 2025Article
- Do osteophytes alter thumb carpometacarpal Biomechanics? a preliminary in vitro study.Journal of biomechanics · 2024Article
- Disease severity versus pain severity: Range of motion differences during single- and multiplanar tasks in women with carpometacarpal osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- The passive biomechanics of the thumb carpometacarpal joint: An in vitro study.Journal of biomechanics · 2024Article
- Characterization of Trapezial Pommel in Relation to Radiographic and Wear Patterns in Carpometacarpal Osteoarthritis.Hand (New York, N.Y.) · 2023Article
- Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation.Bioengineering (Basel, Switzerland) · 2023Article
- Bone morphological changes of the trapezium and first metacarpal with early thumb osteoarthritis progression.Clinical biomechanics (Bristol, Avon) · 2022Article
- An Anatomical Evaluation of the Trapezium and Its Relationship to Basilar Joint Osteophytic Change.Hand (New York, N.Y.) · 2022Article
- Evaluation of the PROMIS Upper Extremity Against Validated Patient-Reported Outcomes in Patients With Early Carpometacarpal Osteoarthritis.The Journal of hand surgery · 2022Article
- Osteophyte volume calculation using dissimilarity-excluding Procrustes registration of archived bone models from healthy volunteers.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOsteophyte formation is a critical part of the degeneration of a joint with osteoarthritis (OA). While often qualitatively described, few studies have succeeded in quantifying osteophyte growth over time. Using computed tomography (CT) image data from a longitudinal, observational study of thumb carpometacarpal (CMC) OA, our aim was to quantify osteophyte growth volume and location over a three-year period in men and women.
methodNinety patients with early thumb OA were recruited and assessed at baseline, 1.5 years, and 3 years with CT imaging. Osteophyte volume and location on the trapezium and first metacarpal were determined using a library of 46 healthy subjects as a nonarthritic reference database.
resultsThere was a significant increase in osteophyte volume for women and men over the three-year follow-up in the trapezium (86.8 mm
conclusionOsteophyte growth occurred in early thumb osteoarthritis over three years. Growth was localized in specific, non-opposing regions on the trapezium and metacarpal, raising intriguing questions about the triggers for their formation, whether the mechanisms are mechanical, biological or a combination of both.
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Registered trials
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