Evidence map›Paper›PMID 31136796›Full record

ArticleJournal of structural biology2019

Structures of two ArsR As(III)-responsive transcriptional repressors: Implications for the mechanism of derepression.

Chandrasekaran Prabaharan, Palani Kandavelu, Charles Packianathan, Barry P Rosen, Saravanamuthu Thiyagarajan

Open access · greenAbstract read
In one paragraph

Article in Journal of structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  3. Article
  4. Article
  5. Mechanisms of Arsenic Interaction inInternational journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. AsJournal of the American Chemical Society · 2024
    Article
  9. Article
  10. Bifunctional protein ArsRBMC microbiology · 2023
    Article
  11. Article
  12. Transcriptional Control ofApplied and environmental microbiology · 2023
    Article
  13. Article
  14. Article
  15. Structural and functional mapping ofComputational and structural biotechnology journal · 2023
    Article
  16. The ArsH Protein Product of theAntioxidants (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chandrasekaran PrabaharanInstitute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka 560100, India. Electronic address: prabaharan@ibab.ac.in.
Palani KandaveluSER-CAT, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address: palani@anl.gov.
Charles PackianathanDepartment of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. Electronic address: cpackian@fiu.edu.
Barry P RosenDepartment of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. Electronic address: brosen@fiu.edu.
Saravanamuthu ThiyagarajanInstitute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka 560100, India. Electronic address: sthiyaga@ibab.ac.in.
Florida International University · USInstitute of Bioinformatics and Applied Biotechnology · IN

Funding

Mechanisms of arsenical transportR37GM055425 · NIGMS · WAYNE STATE UNIVERSITY · PI ROSEN, BARRY P. · 2005 to 2014
$4.4M
Mechanisms of Arsenic Transport and BiotransformationsR01GM055425 · NIGMS · WAYNE STATE UNIVERSITY · PI ROSEN, BARRY P. · 1997 to 2019
$3.8M
MECHANISMS OF ARSENIC TRANSPORT AND BIOTRANSFORMATIONSR35GM136211 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI ROSEN, BARRY P. · 2020 to 2024
$2.3M
Phase II SER-CAT Optimization: Acquisition of a next generation area detectorS10RR028976 · NCRR · UNIVERSITY OF GEORGIA · PI WANG, BI-CHENG · 2010 to 2010
$1.5M
NCRR NIH HHS S10 RR028976NIGMS NIH HHS R01 GM055425NIGMS NIH HHS R35 GM136211NIGMS NIH HHS R37 GM055425
6 · The paper itself

Abstract

ArsR As(III)-responsive transcriptional repressors, members of the ArsR/SmtB family of metalloregulatory proteins, have been characterized biochemically but, to date, no As(III)-bound structure has been solved. Here we report two crystal structures of ArsR repressors from Acidithiobacillus ferrooxidans (AfArsR) and Corynebacterium glutamicum (CgArsR) in the As(III)-bound form. AfArsR crystallized in P2

Indexed as

Protein ConformationAcidithiobacillusAmino Acid SequenceArsenicBacterial ProteinsBinding SitesCorynebacterium glutamicumCrystallography, X-RayDNA-Binding ProteinsMetalsPhylogenyProtein BindingTrans-ActivatorsTranscription, GeneticArsenicBacterial ProteinsDNA-Binding ProteinsMetalsTrans-ActivatorsArsenic bindingArsR-As(III) complexCrystal structuresDerepression

Identifiers

PMID31136796
PMCPMC6689322
OpenAlexW2944954143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.