Evidence map›Paper›PMID 31136648›Full record

ArticleJournal of Crohn's & colitis2020

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network.

J Dhaliwal, T D Walters, D R Mack, H Q Huynh, K Jacobson, A R Otley, J Debruyn, W El-Matary, C Deslandres, M E Sherlock and 14 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 12 institutions in 1 country.

J DhaliwalSickKids Hospital, University of Toronto, Toronto, ON, Canada.
T D WaltersSickKids Hospital, University of Toronto, Toronto, ON, Canada.
D R MackChildren's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
H Q HuynhStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
K JacobsonB.C. Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
A R OtleyIWK Health Centre, Dalhousie University, Halifax, NS, Canada.
J DebruynAlberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
W El-MataryMax Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
C DeslandresCHU Sainte-Justine, Universite de Montreal, Montreal, QC, Canada.
M E SherlockMcMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
J N CritchJaneway Children's Health and Rehabilitation Centre, Memorial University, St John's, NL, Canada.
K BaxChildren's Hospital of Western Ontario, University of Western Ontario, London, ON, Canada.
E SeidmanMontreal Children's Hospital, McGill University Faculty of Medicine, Montreal, QC, Canada.
P JantchouCHU Sainte-Justine, Universite de Montreal, Montreal, QC, Canada.
A RicciutoSickKids Hospital, University of Toronto, Toronto, ON, Canada.
M RashidIWK Health Centre, Dalhousie University, Halifax, NS, Canada.
A M MuiseSickKids Hospital, University of Toronto, Toronto, ON, Canada.
E WineStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
M CarrollStollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
S LawrenceB.C. Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
J Van LimbergenIWK Health Centre, Dalhousie University, Halifax, NS, Canada.
E I BenchimolMontreal Children's Hospital, McGill University Faculty of Medicine, Montreal, QC, Canada.
P ChurchSickKids Hospital, University of Toronto, Toronto, ON, Canada.
A M GriffithsSickKids Hospital, University of Toronto, Toronto, ON, Canada.
University of Toronto · CADalhousie University · CAUniversity of Alberta · CACentre Hospitalier Universitaire Sainte-Justine · CAMontreal Children's Hospital · CAUniversity of British Columbia · CAMcMaster Children's Hospital · CAMemorial University of Newfoundland · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Ottawa · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsIncidence of paediatric inflammatory bowel disease [IBD] in Canada is among the highest worldwide, and age of onset may be decreasing. In a multicentre nationwide inception cohort study, we examined variation in phenotype of IBD throughout the paediatric age spectrum.

methodsChildren aged ≥2 years [y] and <17y [A1 age at diagnosis], with new onset IBD, were systematically evaluated at sites of the Canadian Children IBD Network. Prospectively recorded phenotypic data were compared between age groups.

resultsAmong 1092 children (70% Caucasian; 64% Crohn's disease [CD], 36% ulcerative colitis/inflammatory bowel disease unclassified [UC/IBD-U]; median age 13 y, interquartile range [IQR] 11-15 y), 210 [19%] were diagnosed before the age of age 10 y [Paris A1a] and 43 [4%] before age 6 y (very-early-onset [VEO-IBD]). CD was less common in younger children [42%, 56%, 66%, respectively, of VEO-IBD, A1a; A1b]. Colon-only IBD [UC/IBDU or CD-colon] was present in 81% of VEO-IBD and 65% of A1a; ileal disease increased progressively, reaching plateau at age 10 y. CD location was ileocolonic [L3] in 53% overall. Ileitis [L1] increased with age [6% of VEO-IBD; 13% of A1a; 21% of A1b], as did stricturing/penetrating CD [4% of A1a; 11% of A1b]. At all ages UC was extensive [E3/E4] in >85%, and disease activity moderate to severe according to Physician's Global Assessment [PGA] and weighted Paediatric Crohn's Disease Activity Index/Paediatric Ulcerative Colitis Activity Index [wPCDAI/PUCAI] in >70%. Heights were modestly reduced in CD [mean height z score -0.30 ± 1.23], but normal in UC/IBD-U.

conclusionsParis classification of age at diagnosis is supported by age-related increases in ileal disease until age 10 years. Other phenotypic features, including severity, are similar across all ages. Linear growth is less impaired in CD than in historical cohorts, reflecting earlier diagnosis.

Indexed as

Colitis, UlcerativeCrohn DiseaseAge of OnsetBiological Variation, PopulationCanadaChildCohort StudiesDisease ProgressionFemaleHumansIncidenceMaleProspective StudiesSeverity of Illness IndexIBDpaediatricsphenotype

Identifiers

PMID31136648
PMCPMC7242003
OpenAlexW2947735279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.