Evidence map›Paper›PMID 31136475›Full record

Trial reportPlastic and reconstructive surgery2019

Serum Concentrations and Pharmacokinetics of Tranexamic Acid after Two Means of Topical Administration in Massive Weight Loss Skin-Reducing Surgery.

Kjersti Ausen, Hilde Pleym, Jiayin Liu, Solfrid Hegstad, Håvard Bersås Nordgård, Ivan Pavlovic, Olav Spigset

4 registry-linked trialsAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Plastic and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101124 phase2completednot on this map

Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery

TypeinterventionalSponsorSt. Olavs HospitalRan2017 to 2018Enrolled36ConditionsSurgical Wound, BleedingArmsTranexamic Acid 25 mg/ml for wound surface moistening, Tranexamic Acid 5 mg/ml as bolus in wound cavity, Tranexamic Acid Injectable Solution
NCT04541303 early_phase1completednot on this mapstarted 2020, after this paper: background citation

Randomized Study on the Topical Application of Tranexamic Acid to Wound Bed for Hemostasis in the Setting Granulating Wounds Following Mohs Micrographic Surgery

TypeinterventionalSponsorUniversity of Missouri-ColumbiaRan2020 to 2021Enrolled124ConditionsPostoperative Wound HaemorrhageArmsTranexamic acid, normal saline
NCT05554211 phase2withdrawnnot on this mapstarted 2022, after this paper: background citation

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

TypeinterventionalSponsorNorthwestern UniversityRan2022 to 2024Enrolled0ConditionsBreast Cancer, BRCA MutationArmsTranexamic acid, Normal saline
NCT05708690 phase4completednot on this mapstarted 2022, after this paper: background citation

Topical Application Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery

TypeinterventionalSponsorIndonesia UniversityRan2022 to 2023Enrolled132ConditionsCoronary Artery Disease, Valvular Heart Disease, Surgical Blood LossArmsTranexamic Acid 100 MG/ML, normal saline
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  7. Implementation of a Nebulized Tranexamic Acid Protocol for Pediatric Post-Tonsillectomy Hemorrhage: A Quality Improvement Initiative.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kjersti AusenFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Hilde PleymFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Jiayin LiuFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Solfrid HegstadFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Håvard Bersås NordgårdFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Ivan PavlovicFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.
Olav SpigsetFrom the Section for Plastic and Reconstructive Surgery, Clinic of Surgery, the Clinic of Anesthesia and Intensive Care, and the Department of Clinical Pharmacology, St. Olav's University Hospital; the Departments of Circulation and Medical Imaging and Clinical and Molecular Medicine, Norwegian University of Science and Technology; and the Section for Plastic Surgery, Aleris Medical Center.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTopical administration of tranexamic acid to reduce bleeding is receiving increasing attention, as it is inexpensive, simple, and possibly beneficial in most surgery. Concerns regarding potential systemic adverse effects such as thromboembolic events and seizures may prevent general use of tranexamic acid. Although serum concentrations after topical application are assumed to be low, proper pharmacokinetic studies of tranexamic acid after topical application are lacking.

methodsThe authors have investigated systemic absorption of tranexamic acid after two means of topical administration in patients undergoing abdominoplasty after massive weight loss: a bolus of 200 ml of 5 mg/ml into the wound cavity versus moistening the wound surface with 20 ml of 25 mg/ml. Twelve patients were recruited in each group. Serum concentrations achieved were compared with those after administration of 1 g as an intravenous bolus to arthroplasty patients. Serial blood samples for tranexamic acid analysis were obtained for up to 24 hours.

resultsAfter intravenous administration, the peak serum concentration was 66.1 ± 13.0 µg/ml after 6 ± 2 minutes. Peak serum concentration after topical moistening was 5.2 ± 2.6 µg/ml after 80 ± 33 minutes, and in the topical bolus group, it was 4.9 ± 1.8 µg/ml after 359 ± 70 minutes. Topical moistening resulted in homogenous and predictable absorption across the individuals included, whereas topical bolus administration caused variable and unpredictable serum concentrations.

conclusionTopical administration of tranexamic acid in patients undergoing abdominoplasty results in low serum concentrations, which are highly unlikely to cause systemic effects.

Indexed as

AbdominoplastyAdministration, TopicalAgedAged, 80 and overAntifibrinolytic AgentsFemaleHumansInfusions, IntravenousInjections, IntralesionalMaleMiddle AgedTranexamic AcidWeight LossAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID31136475
PMCPMC6553511

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.