ArticleClinical and translational gastroenterology2019
Altered Functional Connectivity of the Amygdala and Sex Differences in Functional Dyspepsia.
Article in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies.BMC gastroenterology · 2024Pooled it
- Altered resting-state brain activity in functional dyspepsia patients: a coordinate-based meta-analysis.Frontiers in neuroscience · 2023Pooled it
- The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia.Brain imaging and behavior · 2021Trial
- Associations between psychological factors and functional dyspepsia symptoms with consideration of gender differences.Scientific reports · 2026Article
- Factors influencing subjective well-being in individuals with functional dyspepsia - a path analysis of sex and psychological factors.Frontiers in medicine · 2026Article
- Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet.Brain research bulletin · 2023Review
- Aberrant functional brain network dynamics in patients with functional constipation.Human brain mapping · 2021Article
- Abnormalities in the thalamo-cortical network in patients with functional constipation.Brain imaging and behavior · 2021Article
- Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia.BMC gastroenterology · 2021Article
- Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms.Frontiers in psychiatry · 2021Article
- Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences.Journal of neurogastroenterology and motility · 2020Review
- Article
- Associations Between Altered Cerebral Activity Patterns and Psychosocial Disorders in Patients With Psychogenic Erectile Dysfunction: A Mediation Analysis of fMRI.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe influence of sex on the prevalence and clinical manifestations of functional dyspepsia (FD) has recently been a topic of increasing interest. However, brain MRI pathology based on sexual dimorphism in FD has not yet been investigated. The amygdala, which plays a vital role in processing gastrointestinal signals, may be associated with the sex-related pathophysiology of FD.
methodsWe investigated the resting-state functional connectivity (rsFC) of amygdala subregions in patients with FD and healthy subjects as well as the sex differences between male and female FD patients.
resultsThe results showed that FD patients manifested altered rsFC in the basolateral amygdala (BLA) and centromedial amygdala subregions compared with HS and that female FD patients showed increased BLA rsFC with the insula (INS) and decreased BLA rsFC with the medial prefrontal cortex and dorsal lateral prefrontal cortex compared with male FD patients and female HS. DISCUSSION: Our findings suggest that FD females tend to have more severe dysfunction of cognitive-affective processing among the brain regions associated with the salience network, central executive network, and default mode network.
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