ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes.
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Microsatellite instability in penile cancer: comparative analysis of primary tumors and metastases.Frontiers in urology · 2026Article
- Prediction of distant metastases in penile squamous cell carcinoma: a SEER population-based study.International urology and nephrology · 2026Article
- Construction and validation of a prediction model for inguinal lymph node metastasis of penile malignancy.Translational andrology and urology · 2024Article
- Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer.Frontiers in oncology · 2021Article
- Predict Lymph Node Metastasis in Penile Cancer Using Clinicopathological Factors and Nomograms.Cancer management and research · 2021Article
- Lymph Node Dissections for T3T4 Stage Penile Cancer Patients Without Preoperatively Detectable Lymph Node Metastasis Bring More Survival Benefits: A Propensity Matching Analysis.Frontiers in oncology · 2021Article
- Editorial Comment: External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Risk factors for inguinal lymph node metastasis in patients with penile cancer.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Use of flaps in inguinal lymphadenectomy in metastatic penile cancer.International braz j urol : official journal of the Brazilian Society of UrologyReview
- The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Analysis of the related risk factors of inguinal lymph node metastasis in patients with penile cancer: A cross-sectional study.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Predictive histopathological factors of nodal metastasis in penile cancer.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPenile cancer (PC) occurs less frequently in Europe and in the United States than in South America and parts of Africa. Lymph node (LN) involvement is the most important prognostic factor, and inguinal LN (ILN) dissection can be curative; however, ILN dissection has high morbidity. A nomogram was previously developed based on clinicopathological features of PC to predict ILN metastases. Our objective was to conduct an external validation of the previously developed nomogram based on our population. MATERIALS AND
methodsWe included men with cN0 ILNs who underwent ILN dissection for penile carcinoma between 2000 and 2014. We performed external validation of the nomogram considering three different external validation methods: k-fold, leave-oneout, and bootstrap. We also analyzed prognostic variables. Performance was quantified in terms of calibration and discrimination (receiver operator characteristic curve). A logistic regression model for positive ILNs was developed based on clinicopathological features of PC.
resultsWe analyzed 65 men who underwent ILN dissection (cN0). The mean age was 56.8 years. Of 65 men, 24 (36.9%) presented with positive LNs. A median 21 ILNs were removed. Considering the three different methods used, we concluded that the previously developed nomogram was not suitable for our sample.
conclusionsIn our study, the previously developed nomogram that was applied to our population had low accuracy and low precision for correctly identifying patients with PC who have positive ILNs.
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