Evidence map›Paper›PMID 31135262›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Methylation-mediated repression of MiR-424/503 cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23.

Tong Li, Yimin Li, Yaqi Gan, Ruotong Tian, Qihan Wu, Guang Shu, Gang Yin

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. [MicroRNA 424-5p promotes the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting Kinesin family member 23].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  15. Article
  16. Sequence Requirements for miR-424-5p Regulating and Function in Cancers.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tong Lia Department of Pathology , Xiangya Hospital, School of Basic Medical Sciences, Central South University , Changsha , Hunan Province , China.
Yimin Lia Department of Pathology , Xiangya Hospital, School of Basic Medical Sciences, Central South University , Changsha , Hunan Province , China.
Yaqi Gana Department of Pathology , Xiangya Hospital, School of Basic Medical Sciences, Central South University , Changsha , Hunan Province , China.
Ruotong Tianb School of Basic Medical Sciences , Central South University , Changsha , Hunan Province , China.
Qihan Wuc NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Medical School , Fudan University , Shanghai , China.
Guang Shub School of Basic Medical Sciences , Central South University , Changsha , Hunan Province , China.
Gang Yina Department of Pathology , Xiangya Hospital, School of Basic Medical Sciences, Central South University , Changsha , Hunan Province , China.
Central South University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is one type of gynecological malignancies with extremely high lethal rate. Abnormal proliferation and metastasis are regarded to play important roles in patients' death, whereas we know little about the underlying molecular mechanisms. Under this circumstance, our current study aims to investigate the role of hub genes in ovarian cancer. Bioinformatics analysis of the data from GEO and analyses of ovarian cancer samples were performed. Then, the results showed that KIF23, a hub gene, was mainly related to cell cycle and positively associated with poor prognosis. Meanwhile, both miR-424-5p and miR-503-5p directly targeted to 3'UTR of KIF23 to suppress the expression of KIF23 and inhibit ovarian cancer cell proliferation and migration. Furthermore, we discovered that miR-424/503 was epigenetically repressed by hypermethylation in the promoter regions, which directly modulated the expression of KIF23 to improve the oncogenic performance of cancer cells in vitro. Together, our research certifies that miR-424/503 cluster is silenced by DNA hypermethylation, which promotes the expression of KIF23, thereby regulating the proliferation and migration of ovarian cancer cells. Interposing this process might be a novel approach in cancer therapy.

Indexed as

3' Untranslated RegionsCarcinogenesisCarcinoma, Ovarian EpithelialCell CycleCell Line, TumorCell MovementCell ProliferationDatabases, Nucleic AcidDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsMicrotubule-Associated ProteinsOligonucleotide Array Sequence AnalysisOvarian Neoplasms3' Untranslated RegionsKIF23 protein, humanMicroRNAsMicrotubule-Associated ProteinsMIRN424 microrna, humanMIRN503 microRNA, humanKIF23MethylationMiR-424/503 clusterovarian cancer

Identifiers

PMID31135262
PMCPMC6619937
OpenAlexW2947322979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.