Evidence map›Paper›PMID 31135093›Full record

ArticleStem cells (Dayton, Ohio)2019

Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation.

Anna Shcherbina, Jingling Li, Cyndhavi Narayanan, William Greenleaf, Anshul Kundaje, Sundari Chetty

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. PI3K in stemness regulation: from development to cancer.Biochemical Society transactions · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anna ShcherbinaDepartment of Biomedical Informatics, Stanford University, Stanford, California, USA.
Jingling LiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Cyndhavi NarayananDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
William GreenleafDepartment of Genetics, Stanford University, Stanford, California, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, California, USA.
Sundari ChettyDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-1940-9538
Stanford University · USStanford Medicine · USCalifornia Institute for Regenerative Medicine · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Deep learning frameworks for regulatory genomics.DP2GM123485 · NIGMS · STANFORD UNIVERSITY · PI KUNDAJE, ANSHUL · 2016 to 2016
$2.4M
High Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596k
NIGMS NIH HHS DP2 GM123485NIH HHS S10 OD018220U.S. National Institutes of Health S10OD018220
6 · The paper itself

Abstract

Understanding the molecular properties of the cell cycle of human pluripotent stem cells (hPSCs) is critical for effectively promoting differentiation. Here, we use the Fluorescence Ubiquitin Cell Cycle Indicator system adapted into hPSCs and perform RNA sequencing on cell cycle sorted hPSCs primed and unprimed for differentiation. Gene expression patterns of signaling factors and developmental regulators change in a cell cycle-specific manner in cells primed for differentiation without altering genes associated with pluripotency. Furthermore, we identify an important role for PI3K signaling in regulating the early transitory states of hPSCs toward differentiation. Stem Cells 2019;37:1151-1157.

Indexed as

Gene Regulatory NetworksCell CycleCell DifferentiationCells, CulturedGene Expression ProfilingHumansPhosphatidylinositol 3-KinasesPluripotent Stem CellsSequence Analysis, RNASignal TransductionPhosphatidylinositol 3-Kinases

Identifiers

PMID31135093
PMCPMC6711778
OpenAlexW2912459160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.