ReviewPhysiological reports2019
Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones.
Review in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Effects of different Metabolic Bariatric Surgeries in Testosterone Levels: A Systematic Review and Meta-Analysis.Obesity surgery · 2025Pooled it
- Meta-analysis of changes in skeletal muscle mass within 1 year after bariatric surgery.Surgical endoscopy · 2025Pooled it
- Associations between COVID-19 infection and sex steroid hormones.Frontiers in endocrinology · 2022Pooled it
- Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women.International journal of environmental research and public health · 2020Pooled it
- Effectiveness of combining Qingyanyin formulated granules with press needles in treating abdominal obesity: a multicenter randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Trial
- Bariatric surgery and risk of dementia and Parkinson's disease in patients with obesity.International journal of obesity (2005) · 2026Article
- The Influence of Laparscopic Sleeve Gastrectomy on Male Erectile Function among Morbid Obese Patients: an Observational Study.Obesity surgery · 2026Observational
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Long-Term Cancer Outcomes Following Bariatric Surgery: A Comparative Analysis of Surgical Procedures.Cancers · 2024Article
- A roadmap for clinical trials in MASH-related compensated cirrhosis.Nature reviews. Gastroenterology & hepatology · 2024Review
- The impact of sleeve gastrectomy on polycystic ovarian syndrome: a single-center 1-year cohort study.Irish journal of medical science · 2024Article
- Sleeve gastrectomy as a bridge to maternity in a patient with obesity, infertility and tetraplegia. A case report.Spinal cord series and cases · 2024Article
- Long-term trajectories of bone metabolism parameters and bone mineral density (BMD) in obese patients treated with metabolic surgery: a real-world, retrospective study.Journal of endocrinological investigation · 2023Article
- Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery.Journal of clinical medicine · 2023Article
- Development of dementia in patients who underwent bariatric surgery.Surgical endoscopy · 2023Article
- Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy.Nutrients · 2023Review
- Long-Term Changes in Bone Density and Bone Metabolism After Gastric Bypass Surgery: a Retrospective Cohort Study.Obesity surgery · 2023Article
- Bariatric Artery Embolization for Obese Patients. An Up-to-Date Review.Journal of the Belgian Society of Radiology · 2023Article
- The relationship between anti-Müllerian hormone, body mass index and weight loss: A review of the literature.Clinical obesity · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bariatric surgery is now the most widely used intervention for the treatment of human obesity. A large body of literature has demonstrated its efficacy in sustained weight loss and improvement in its associated comorbidities. Here, we review the effect of bariatric surgery in gut hormone physiology, bone remodeling and the reproductive axis. Rapid improvements in insulin release and sensitivity appear to be weight loss independent and occur immediately after surgery. These effects on pancreatic beta cells are mostly due to increased gut hormone secretion due to augmented nutrient delivery to the small intestine. Bone remodeling is also affected by gut hormones. Phenotypic skeletal changes observed in mice deficient in GLP-1 or GIP suggest that increased incretins may improve bone density. However, these positive effects may be counterbalanced by the association between weight loss and a reduction in bone density. Finally, studies have shown a marked improvement following bariatric surgery in infertility and PCOS in women and hypogonadism in men. Thus, the net effect on endocrine systems after bariatric surgery will likely vary on an individual basis and depend on factors such as comorbidities, peri-menopausal state, amount of weight loss, and likelihood to adhere to vitamin supplementation after surgery.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.