Evidence map›Paper›PMID 31134643›Full record

ReviewAnnals of the New York Academy of Sciences2019

Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries.

Megan W Bourassa, Saskia J M Osendarp, Seth Adu-Afarwuah, Saima Ahmed, Clayton Ajello, Gilles Bergeron, Robert Black, Parul Christian, Simon Cousens, Saskia de Pee and 19 more

3 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 62 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 11 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05312242 nacompletednot on this mapstarted 2022, after this paper: background citation

Introduction of Multiple Micronutrient Supplementation to Antenatal Care in Bamako, Mali

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2022 to 2023Enrolled486ConditionsAdherence, MedicationArmsUnited Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) MMS, Iron Folic Acid Supplement
NCT06810440 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reducing Anemia Among Young Preconception Women in Nepal Through a Group Household Norm and Micronutrient Supplementation Intervention

TypeinterventionalSponsorUniversity of California, San FranciscoRan2025 to 2029Enrolled2,100ConditionsAnemia, Iron-Deficiency, Nutritional Deficiencies, Adherence, Norms, SocialArmsSumadhur, Multiple micronutrient supplement MMS
NCT07029282 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase III Double-Blind, Adaptive Randomized Trial of Antenatal MMSPlus Versus UNIMAPP MMS and Postnatal MMSPlus Versus UNIMAPP MMS or IFA to Improve Infant Birth Outcomes and Growth at 6 Months

TypeinterventionalSponsorAga Khan UniversityRan2025 to 2027Enrolled3,000ConditionsNewborn Health, Multiple Micronutrient Deficiencies During Pregnancy, Nutrition During Pregnancy, Adaptive TrialArmsMMS, MMS Plus, IFA
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 11 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 18 institutions in 10 countries.

Megan W BourassaThe New York Academy of Sciences, New York, New York.
Saskia J M OsendarpOsendarp Nutrition, Berkel & Rodenrijs, the Netherlands.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana.
Saima AhmedThe New York Academy of Sciences, New York, New York.
Clayton AjelloThe Vitamin Angels Alliance, Inc., Santa Barbara, California.
Gilles BergeronThe New York Academy of Sciences, New York, New York.
Robert BlackJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Parul ChristianJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Simon CousensLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Saskia de PeeDivision of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.
Kathryn G DeweyDepartment of Nutrition, University of California, Davis, Davis, California.
Shams El ArifeenInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Reina Engle-StoneDepartment of Nutrition, University of California, Davis, Davis, California.
Alison FleetUNICEF, Copenhagen, Denmark.
Alison D GernandThe Pennsylvania State University, State College, Pennsylvania.
John HoddinottDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Rolf KlemmThe Vitamin Angels Alliance, Inc., Santa Barbara, California.
Klaus KraemerSight and Life Foundation, Basel, Switzerland.
Roland KupkaUNICEF, New York, New York.
Erin McLeanUNICEF, New York, New York.
Sophie E MooreDepartment of Women and Children's Health, King's College London, London, United Kingdom.
Lynnette M NeufeldGlobal Alliance for Improved Nutrition GAIN, Geneva, Switzerland.
Lars-Åke PerssonLondon School of Hygiene and Tropical Medicine, Addis Ababa, Ethiopia.
Kathleen M RasmussenDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Anuraj H ShankarDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Emily SmithBill & Melinda Gates Foundation, Seattle, Washington.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Emorn UdomkesmaleeInstitute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
Stephen A VostiDepartment of Nutrition, University of California, Davis, Davis, California.
New York Academy of Sciences · USUnited Nations Children's Fund · USUniversity of California, Davis · USAngela Boškin Faculty of Health Care · SIBill & Melinda Gates Foundation · USCornell University · USHarvard Global Health Institute · USLondon School of Hygiene & Tropical Medicine · GBGlobal Alliance for Improved Nutrition · CHInternational Centre for Diarrhoeal Disease Research · BDJohns Hopkins University · USKing's College London · GBMahidol University · THPennsylvania State University · USSight and Life · CHUniversity of Ghana · GHWageningen University & Research · NLWorld Food Programme · IT

Funding

Medical Research Council MC_PC_MR/R019177/1Medical Research Council MC_U123292701Medical Research Council MR/P012019/1
6 · The paper itself

Abstract

Inadequate micronutrient intakes are relatively common in low- and middle-income countries (LMICs), especially among pregnant women, who have increased micronutrient requirements. This can lead to an increase in adverse pregnancy and birth outcomes. This review presents the conclusions of a task force that set out to assess the prevalence of inadequate micronutrient intakes and adverse birth outcomes in LMICs; the data from trials comparing multiple micronutrient supplements (MMS) that contain iron and folic acid (IFA) with IFA supplements alone; the risks of reaching the upper intake levels with MMS; and the cost-effectiveness of MMS compared with IFA. Recent meta-analyses demonstrate that MMS can reduce the risks of preterm birth, low birth weight, and small for gestational age in comparison with IFA alone. An individual-participant data meta-analysis also revealed even greater benefits for anemic and underweight women and female infants. Importantly, there was no increased risk of harm for the pregnant women or their infants with MMS. These data suggest that countries with inadequate micronutrient intakes should consider supplementing pregnant women with MMS as a cost-effective method to reduce the risk of adverse birth outcomes.

Indexed as

Dietary SupplementsDeveloping CountriesFemaleHumansInfant, NewbornMicronutrientsPregnancyPregnancy OutcomeMicronutrientsLMICsmicronutrientpregnancysupplements

Identifiers

PMID31134643
PMCPMC6852202
OpenAlexW2947512134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.