ArticleThe British journal of surgery2019
Predicting reamputation risk in patients undergoing lower extremity amputation due to the complications of peripheral artery disease and/or diabetes.
Article in The British journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Outcomes following major dysvascular lower limb amputation: an updated systematic review.BMC cardiovascular disorders · 2026Pooled it
- A Systematic Review and Narrative Synthesis of Risk Prediction Tools Used to Estimate Mortality, Morbidity, and Other Outcomes Following Major Lower Limb Amputation.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2021Pooled it
- Lower extremity reamputation in people with diabetes: a systematic review and meta-analysis.BMJ open diabetes research & care · 2021Pooled it
- Using Natural Language Processing to Measure and Improve Quality of Diabetes Care: A Systematic Review.Journal of diabetes science and technology · 2021Pooled it
- Lower extremity amputations in Switzerland: Trends in patients with and without diabetes, 2013-2023.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Delta Neutrophil Index as an Early Screening and Prognostic Marker for Revision after Non-traumatic Below-Knee Amputation: A Hospital-Based Study.Clinics in orthopedic surgery · 2026Article
- Development of risk prediction model for major amputation in patients with diabetic foot.BMC endocrine disorders · 2026Article
- PROPREDICT Decision Support Tool: Using Evidence to Guide Precision Prosthesis Prescription and Rehabilitation Planning.Archives of physical medicine and rehabilitation · 2026Article
- Article
- AMPREDICT Mobility-4: A Novel Four Category Mobility Outcome Prediction Model for Patients Undergoing Vascular Amputation.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2025Article
- Skin perfusion pressure, distal blood pressure vs. trans cutaneous oxygen pressure for predicting wound healing after major amputation.Clinical physiology and functional imaging · 2025Article
- AMPREDICT MoRe: Predicting Mortality and Re-amputation Risk after Dysvascular Amputation.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2025Article
- Predicting Functional Outcomes Following Dysvascular Lower Limb Amputation: An Evidence Review of Personalizing Patient Outcomes.Physical medicine and rehabilitation clinics of North America · 2024Review
- Major Lower Limb Amputation for Chronic Limb-Threatening Ischemia Is Associated with Poor Long-Term Survival: 4-Year Follow-Up of a Single-Center Experience.Annals of vascular diseases · 2024Article
- Risk Factors for Unplanned Higher-Level Re-Amputation and Mortality after Lower Extremity Amputation in Chronic Limb-Threatening Ischemia.Journal of clinical medicine · 2024Article
- Development of the AMPDECIDE Decision Aid to Facilitate Shared Decision Making in Patients Facing Amputation Secondary to Chronic Limb Threatening Ischemia.The Journal of surgical research · 2024Article
- Long-term risk prediction after major lower limb amputation: 1-year results of the PERCEIVE study.BJS open · 2024Observational
- Comparing Patient and Provider Priorities Around Amputation Level Outcomes Using Multiple Criteria Decision Analysis.Annals of vascular surgery · 2023Article
- Differences in Prosthetic Prescription Between Men and Women Veterans After Transtibial or Transfemoral Lower-Extremity Amputation: A Longitudinal Cohort Study (2005-2018).Archives of physical medicine and rehabilitation · 2023Article
- AMPREDICT PROsthetics-Predicting Prosthesis Mobility to Aid in Prosthetic Prescription and Rehabilitation Planning.Archives of physical medicine and rehabilitation · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPatients undergoing amputation of the lower extremity for the complications of peripheral artery disease and/or diabetes are at risk of treatment failure and the need for reamputation at a higher level. The aim of this study was to develop a patient-specific reamputation risk prediction model.
methodsPatients with incident unilateral transmetatarsal, transtibial or transfemoral amputation between 2004 and 2014 secondary to diabetes and/or peripheral artery disease, and who survived 12 months after amputation, were identified using Veterans Health Administration databases. Procedure codes and natural language processing were used to define subsequent ipsilateral reamputation at the same or higher level. Stepdown logistic regression was used to develop the prediction model. It was then evaluated for calibration and discrimination by evaluating the goodness of fit, area under the receiver operating characteristic curve (AUC) and discrimination slope.
resultsSome 5260 patients were identified, of whom 1283 (24·4 per cent) underwent ipsilateral reamputation in the 12 months after initial amputation. Crude reamputation risks were 40·3, 25·9 and 9·7 per cent in the transmetatarsal, transtibial and transfemoral groups respectively. The final prediction model included 11 predictors (amputation level, sex, smoking, alcohol, rest pain, use of outpatient anticoagulants, diabetes, chronic obstructive pulmonary disease, white blood cell count, kidney failure and previous revascularization), along with four interaction terms. Evaluation of the prediction characteristics indicated good model calibration with goodness-of-fit testing, good discrimination (AUC 0·72) and a discrimination slope of 11·2 per cent.
conclusionA prediction model was developed to calculate individual risk of primary healing failure and the need for reamputation surgery at each amputation level. This model may assist clinical decision-making regarding amputation-level selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.