ArticleHuman genetics2020
Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data.
Article in Human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease.MedScience · 2026Review
- Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging.npj aging · 2025Article
- The effects of loss of Y chromosome on male health.Nature reviews. Genetics · 2025Review
- Identifying X-chromosome variants associated with age-related macular degeneration.Human molecular genetics · 2024Article
- Why Y matters? The implication of loss of Y chromosome in blood and cancer.Cancer science · 2024Review
- Circulating macrophages as the mechanistic link between mosaic loss of Y-chromosome and cardiac disease.Cell & bioscience · 2023Article
- Characterization of loss of chromosome Y in peripheral blood cells in male Han Chinese patients with schizophrenia.BMC psychiatry · 2023Article
- Clonal hematopoiesis, somatic mosaicism, and age-associated disease.Physiological reviews · 2023Review
- Genetic association of mosaic loss of chromosome Y with prostate cancer in men of European and East Asian ancestries: a Mendelian randomization study.Frontiers in aging · 2023Article
- Reducing the aneuploid cell burden - cell competition and the ribosome connection.Disease models & mechanisms · 2022Review
- Mosaic loss of chromosome Y in peripheral blood cells is associated with age-related macular degeneration in men.Cell & bioscience · 2022Article
- Rats exhibit age-related mosaic loss of chromosome Y.Communications biology · 2021Article
- A reply to: Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals.European journal of human genetics : EJHG · 2021Article
- Reply to Veitia.European journal of human genetics : EJHG · 2021Article
- Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells.Haematologica · 2021Article
- Neovascular age-related macular degeneration presenting at extremities of age: a comparative study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Mosaic loss of human Y chromosome: what, how and why.Human genetics · 2020Review
- Special issue on "Molecular genetics of aging and longevity": a critical time in the field of geroscience.Human genetics · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
The extent of aneuploidy of the sex chromosomes increases with age in human leukocytes. Here, we re-explore the dynamics of normal loss of the Y chromosome (LOY) with age based on microarray data using two exponential models and two different ways to estimate the fraction of LOY. This analysis shows the existence of a significant correlation between the fraction of LOY estimated from molecular cytogenetics and genotyping microarray data. Although the specific estimates of the parameters for the two exponential models are different from those derived from cytogenetics data, the present analysis in an independent dataset of normal individuals confirms that X0 cells have a selective advantage over XY cells. Moreover, patients with age-related macular degeneration display higher fraction of LOY values and seem to have a predisposition to lose their Y chromosome even at young ages compared to control individuals. As there are no data available for the same individuals at different time points, the parameters reported here are average values drawn from population analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.