Evidence map›Paper›PMID 31134330›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2020

When and how do patients with cardiac amyloidosis die?

F Escher, M Senoner, J Doerler, M M Zaruba, M Messner, C Mussner-Seeber, M Ebert, C Ensinger, A Mair, A Kroiss and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Research Priorities and Future Directions in Cardio-Oncology.Current treatment options in oncology · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Cardiac Amyloidosis: Tribulations and New Frontiers.Journal of personalized medicine · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

F EscherClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
M SenonerClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
J DoerlerClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
M M ZarubaClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
M MessnerClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
C Mussner-SeeberClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
M EbertClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
C EnsingerDepartment of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
A MairDepartment of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
A KroissDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
H UlmerDepartment of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
S Schneiderbauer-PorodDepartment of Cardiology, Ordensklinikum Elisabethinen Linz, Linz, Austria.
C EbnerDepartment of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
G PoelzlClinical Division of Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. gerhard.poelzl@tirol-kliniken.at.
Universität Innsbruck · ATInnsbruck Medical University · ATKrankenhaus der Elisabethinen · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac amyloidosis (CA) is an underappreciated cause of morbidity and mortality. Light-chain (AL) and transthyretin (ATTR) amyloidosis have different disease trajectories. No data are available on subtype-specific modes of death (MOD) in patients with CA. METHODS AND

resultsWe retrospectively investigated 66 with AL and 48 with wild-type ATTR amyloidosis (ATTRwt) from 2000 to 2018. ATTRwt differed from AL by age (74.6 ± 5.4 years vs. 63 ± 10.8 years), posterior wall thickness (16.8 ± 3.3 mm vs. 14.3 ± 2.2 mm), left ventricular mass index (180.7 ± 63.2 g/m

conclusionOur data indicate no differences in MOD between patients with AL and ATTRwt cardiac amyloidosis despite significant differences in clinical presentation and disease progression. Cardiovascular events account for more than two-thirds of fatal casualties in both groups.

Indexed as

AgedAged, 80 and overAmyloidosisAtrial FibrillationCardiomyopathiesCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansImmunoglobulin Light-chain AmyloidosisMaleMiddle AgedPrealbuminRetrospective StudiesPrealbuminCardiac amyloidosisLight chain (AL) amyloidosisMode of deathPrognosisTransthyretin (ATTR) amyloidosis

Identifiers

PMID31134330
PMCPMC6952329
OpenAlexW2947295952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.