Evidence map›Paper›PMID 31134177›Full record

ArticleFrontiers in chemistry2019

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors.

Daniel T G Gonzaga, Felipe H Oliveira, N L von Ranke, G Q Pinho, Juliana P Salles, Murilo L Bello, Carlos R Rodrigues, Helena C Castro, Hellen V C M de Souza, Caroline R C Reis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Molluscicidal and Schistosomicidal Activities of 2-(1Pharmaceuticals (Basel, Switzerland) · 2025
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  7. Ruscogenin Ameliorated Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Daniel T G GonzagaDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Felipe H OliveiraLaboratório de Toxoplasmose e Outras Protozooses, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
N L von RankeDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
G Q PinhoLaboratório de Toxoplasmose e Outras Protozooses, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Juliana P SallesLaboratório de Toxoplasmose e Outras Protozooses, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Murilo L BelloDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Carlos R RodriguesDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Helena C CastroLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular-LABiEMol, Universidade Federal Fluminense, Niterói, Brazil.
Hellen V C M de SouzaDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Caroline R C ReisDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Rennan P P LemeDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
João C M MafraDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Luiz C S PinheiroDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Lucas V B HoelzDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Nubia BoechatDepartamento de Síntese de Fármacos Manguinhos, Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil.
Robson X FariaInstituto Biomédico, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Estadual da Zona Oeste · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twenty new 2-(1

Indexed as

dye uptakeIL-1β releasemolecular dockingP2X7 receptorpaw edemapyrazolethiadiazole

Identifiers

PMID31134177
PMCPMC6511888
OpenAlexW2943009190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.