ArticleFrontiers in pediatrics2019
Propranolol 0.2% Eye Micro-Drops for Retinopathy of Prematurity: A Prospective Phase IIB Study.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis.Paediatric drugs · 2024Pooled it
- Clinical Efficacy and Safety of Propranolol in the Prevention and Treatment of Retinopathy of Prematurity: A Meta-Analysis of Randomized Controlled Trials.Frontiers in pediatrics · 2021Pooled it
- Effect of oral propranolol on clinical findings and complications in retinopathy of premature infants: a randomized controlled trial.Annals of medicine and surgery (2012) · 2026Article
- Research progress on the use of beta-blockers in the progression prevention, and treatment of retinopathy of prematurity.Frontiers in pediatrics · 2026Review
- Review of Retinopathy of Prematurity Management in the Anti-VEGF Era: Evolving Global Paradigms, Persistent Challenges and Our AI-Assisted Future.Clinical & experimental ophthalmology · 2025Review
- Optimizing instilled drug delivery: a scoping review of microdrops in ophthalmology.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- [Advances in pharmacological research for retinopathy of prematurity].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Retinopathy of prematurity in the era of precision neonatology: from risk stratification to targeted therapies.World journal of pediatrics : WJP · 2025Article
- Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system.Scientific reports · 2025Article
- Emerging opportunities in ROP therapy: from inhibiting pathological vessel growth to promoting physiological vascularization.Frontiers in medicine · 2025Review
- The Current and Potential Role of Pediatric Clinical Pharmacologists in Italy: A Review with Evidence Synthesis and Literature Analysis.Current medicinal chemistry · 2025Review
- Beyond anti-VEGF: expanding the therapeutic horizon and biomarker landscape in retinopathy of prematurity.Frontiers in pediatrics · 2025Review
- Article
- β3-adREnoceptor Analysis in CORD Blood of Neonates (β3 RECORD): Study Protocol of a Pilot Clinical Investigation.Life (Basel, Switzerland) · 2024Article
- Retinopathy of Prematurity-Targeting Hypoxic and Redox Signaling Pathways.Antioxidants (Basel, Switzerland) · 2024Review
- Propranolol: a new pharmacologic approach to counter retinopathy of prematurity progression.Frontiers in pediatrics · 2024Review
- A promising case of preclinical-clinical translation: β-adrenoceptor blockade from the oxygen-induced retinopathy model to retinopathy of prematurity.Frontiers in physiology · 2024Review
- Retinopathy of prematurity: from oxygen management to molecular manipulation.Molecular and cellular pediatrics · 2023Review
- Modifiable Risk Factors and Preventative Strategies for Severe Retinopathy of Prematurity.Life (Basel, Switzerland) · 2023Review
- New Aspects on the Treatment of Retinopathy of Prematurity: Currently Available Therapies and Emerging Novel Therapeutics.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 12 institutions in 2 countries.
Luca FilippiNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, "A. Meyer" University Children's Hospital, Florence, Italy.
Giacomo CavallaroNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Elettra BertiNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, "A. Meyer" University Children's Hospital, Florence, Italy.
Letizia PadriniNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, "A. Meyer" University Children's Hospital, Florence, Italy.
Gabriella AraimoNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Giulia RegiroliNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Genny RaffaeliNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Valentina BozzettiNeonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital, Monza, Italy.
Paolo TagliabueNeonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital, Monza, Italy.
Barbara TomasiniNeonatal Intensive Care Unit, University Hospital of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
Annalisa MoriDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Giuseppe BuonocoreDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Massimo AgostiNeonatal Intensive Care Unit, Del Ponte Hospital, Varese, Italy.
Angela BossiNeonatal Intensive Care Unit, Del Ponte Hospital, Varese, Italy.
Gaetano ChiricoNeonatal Intensive Care Unit, Children's Hospital, University Hospital "Spedali Civili" of Brescia, Brescia, Italy.
Salvatore AversaNeonatal Intensive Care Unit, Children's Hospital, University Hospital "Spedali Civili" of Brescia, Brescia, Italy.
Pina FortunatoPediatric Ophthalmology, "A. Meyer" University Children's Hospital, Florence, Italy.
Silvia OsnaghiDepartment of Ophthalmology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milan, Milan, Italy.
Barbara CavallottiDepartment of Ophthalmology, ASST Monza, San Gerardo Hospital, Monza, Italy.
Martina SuzaniDepartment of Ophthalmology, ASST Monza, San Gerardo Hospital, Monza, Italy.
Maurizio VanniPediatric Ophthalmology, University Hospital of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
Giulia BorsariPediatric Ophthalmology, University Hospital of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
Simone DonatiDepartment of Surgical and Morphological Sciences, Section of Ophthalmology, University of Insubria, Varese, Italy.
Giuseppe NascimbeniDepartment of Ophthalmology, University Hospital "Spedali Civili" of Brescia, Brescia, Italy.
Daniel NardoDepartment of Women's and Children's Health, Azienda Ospedaliera di Padova, University of Padua, Padua, Italy.
Stefano PiermarocchiDepartment of Ophthalmology, University of Padua, Padua, Italy.
Giancarlo la MarcaNewborn Screening, Biochemistry and Pharmacology Laboratory, Meyer Children's University Hospital, Florence, Italy.
Giulia ForniNewborn Screening, Biochemistry and Pharmacology Laboratory, Meyer Children's University Hospital, Florence, Italy.
Silvano MilaniLaboratory "G.A. Maccacro," Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Ivan CortinovisLaboratory "G.A. Maccacro," Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Maura CalvaniOncohematology Unit, Department of Pediatric Oncology, "A. Meyer" University Children's Hospital, Florence, Italy.
Paola BagnoliDepartment of Biology, Unit of General Physiology, University of Pisa, Pisa, Italy.
Massimo Dal MonteDepartment of Biology, Unit of General Physiology, University of Pisa, Pisa, Italy.
Anna Maria CalvaniDepartment of Pharmacy, "A. Meyer" University Children's Hospital, Florence, Italy.
Alessandra PugiClinical Trial Office, "A. Meyer" University Children's Hospital, Florence, Italy.
Eduardo VillamorDepartment of Pediatrics, Maastricht University Medical Center, School for Oncology and Developmental Biology, Maastricht, Netherlands.
Gianpaolo DonzelliNeonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, "A. Meyer" University Children's Hospital, Florence, Italy.
Fabio MoscaNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Meyer Children's Hospital · ITUniversity of Milan · ITAzienda Ospedaliera San Gerardo · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale Santa Maria alle Scotte · ITOspedale Filippo Del Ponte Varese · ITUniversity of Padua · ITUniversity of Pisa · ITUniversity of Siena · ITMaastricht University · NLUniversity of Insubria · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
angiogenesisbeta blockerpreterm newbornproliferative retinopathypropranolol
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.