Evidence map›Paper›PMID 31134108›Full record

ReviewFrontiers in plant science2019

Harnessing Genome Editing Techniques to Engineer Disease Resistance in Plants.

Muntazir Mushtaq, Aafreen Sakina, Shabir Hussain Wani, Asif B Shikari, Prateek Tripathi, Abbu Zaid, Aravind Galla, Mostafa Abdelrahman, Manmohan Sharma, Anil Kumar Singh and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Muntazir MushtaqSchool of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu, India.
Aafreen SakinaDivision of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, India.
Shabir Hussain WaniMountain Research Center for Field Crops, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, India.
Asif B ShikariDivision of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, India.
Prateek TripathiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Abbu ZaidPlant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh, India.
Aravind GallaDepartment of Entomology, University of Arkansas, Fayetteville, AR, United States.
Mostafa AbdelrahmanArid Land Research Center, Tottori University, Tottori, Japan.
Manmohan SharmaSchool of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu, India.
Anil Kumar SinghSchool of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu, India.
Romesh Kumar SalgotraSchool of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu, India.
Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu · INSher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir · INAligarh Muslim University · INScripps Research Institute · USTottori University · JPUniversity of Arkansas at Fayetteville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern genome editing (GE) techniques, which include clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) system, transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs) and LAGLIDADG homing endonucleases (meganucleases), have so far been used for engineering disease resistance in crops. The use of GE technologies has grown very rapidly in recent years with numerous examples of targeted mutagenesis in crop plants, including gene knockouts, knockdowns, modifications, and the repression and activation of target genes. CRISPR/Cas9 supersedes all other GE techniques including TALENs and ZFNs for editing genes owing to its unprecedented efficiency, relative simplicity and low risk of off-target effects. Broad-spectrum disease resistance has been engineered in crops by GE of either specific host-susceptibility genes (

Indexed as

CRISPR/Cas9genome editinghoming endonucleasesphytopathogensplant diseasestress

Identifiers

PMID31134108
PMCPMC6514154
OpenAlexW2944535522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.