Evidence map›Paper›PMID 31133828›Full record

ArticleFrontiers in behavioral neuroscience2019

Differential Associations of Deprivation and Threat With Cognitive Control and Fear Conditioning in Early Childhood.

Laura Machlin, Adam Bryant Miller, Jenna Snyder, Katie A McLaughlin, Margaret A Sheridan

Abstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  15. The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  16. Article
  17. Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Research Review: Assessment of early-life adversity and trauma - cumulative risk and dimensional approaches.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura MachlinDepartment of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Adam Bryant MillerDepartment of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jenna SnyderCooper Medical School of Rowan University, Camden, NJ, United States.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, MA, United States.
Margaret A SheridanDepartment of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
Human Development: Interdisiplinary Research TrainingT32HD007376 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL, PROPPER, CATHI BARBRA · 1988 to 2020
$8.0M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
Testing the predictive power of neural connectivity: Suicidal ideation in youth exposed to maltreatmentK01MH116325 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, ADAM BRYANT · 2018 to 2022
$898k
NCATS NIH HHS UL1 TR002489NICHD NIH HHS T32 HD007376NIMH NIH HHS K01 MH116325NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH106482
6 · The paper itself

Abstract

Early-life adversity (ELA) is strongly associated with risk for psychopathology. Within adversity, deprivation, and threat may lead to psychopathology through different intermediary pathways. Specifically, deprivation, defined as the absence of expected cognitive and social inputs, is associated with lower performance on complex cognitive tasks whereas threatening experiences, defined as the presence of experiences that reflect harm to the child, are associated with atypical fear learning and emotional processes. However, distinct associations of deprivation and threat on behavioral outcomes have not been examined in early childhood. The present study examines how deprivation and threat are associated with cognitive and emotional outcomes in early childhood. Children 4-7 years old completed behavioral tasks assessing cognitive control (

Indexed as

cognitive controldeprivationfear conditioningphysiological reactivitythreat

Identifiers

PMID31133828
PMCPMC6517554

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.