Evidence map›Paper›PMID 31133812›Full record

ArticleFrontiers in cellular neuroscience2019

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain.

Ksenia Koroleva, Oleg Gafurov, Valeriia Guselnikova, Dilyara Nurkhametova, Raisa Giniatullina, Guzel Sitdikova, Olli S Mattila, Perttu J Lindsberg, Tarja Maarit Malm, Rashid Giniatullin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of ATP in migraine mechanisms: focus on P2X3 receptors.The journal of headache and pain · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. DecipheringFrontiers in cellular neuroscience · 2021
    Article
  20. Involvement of Mast Cells in the Pathophysiology of Pain.Frontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ksenia KorolevaLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Oleg GafurovLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Valeriia GuselnikovaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Dilyara NurkhametovaLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Raisa GiniatullinaA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Guzel SitdikovaLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Olli S MattilaDepartment of Neurology and Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Perttu J LindsbergDepartment of Neurology and Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tarja Maarit MalmA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Rashid GiniatullinLaboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
Kazan Federal University · RUUniversity of Eastern Finland · FIUniversity of Helsinki · FIInstitute of Experimental Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral mechanisms of primary headaches such as a migraine remain unclear. Meningeal afferents surrounded by multiple mast cells have been suggested as a major source of migraine pain. Extracellular ATP released during migraine attacks is a likely candidate for activating meningeal afferents via neuronal P2X receptors. Recently, we showed that ATP also increased degranulation of resident meningeal mast cells (Nurkhametova et al., 2019). However, the contribution of ATP-induced mast cell degranulation in aggravating the migraine pain remains unknown. Here we explored the role of meningeal mast cells in the pro-nociceptive effects of extracellular ATP. The impact of mast cells on ATP mediated activation of peripheral branches of trigeminal nerves was measured electrophysiologically in the dura mater of adult wild type (WT) or mast cell deficient mice. We found that a spontaneous spiking activity in the meningeal afferents, at baseline level, did not differ in two groups. However, in WT mice, meningeal application of ATP dramatically (24.6-fold) increased nociceptive firing, peaking at frequencies around 10 Hz. In contrast, in mast cell deficient animals, ATP-induced excitation was significantly weaker (3.5-fold). Application of serotonin to meninges in WT induced strong spiking. Moreover, in WT mice, the 5-HT3 antagonist MDL-7222 inhibited not only serotonin but also the ATP induced nociceptive firing. Our data suggest that extracellular ATP activates nociceptive firing in meningeal trigeminal afferents via amplified degranulation of resident mast cells in addition to direct excitatory action on the nerve terminals. This highlights the importance of mast cell degranulation via extracellular ATP, in aggravating the migraine pain.

Indexed as

5-HT3ATPmast cellsmigrainepain

Identifiers

PMID31133812
PMCPMC6524559
OpenAlexW2943942743

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.