Evidence map›Paper›PMID 31133809›Full record

ArticleFrontiers in cellular neuroscience2019

Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study.

John Joseph Wade, Kevin Breslin, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Mark Dallas, Angela Bithell, Alexei Verkhratsky and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023
    Review
  6. Review
  7. Physiology of Astroglial Excitability.Function (Oxford, England) · 2020
    Article
  8. Astrocytic Calcium Dynamics Along the Pain Pathway.Frontiers in cellular neuroscience · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John Joseph WadeComputational Neuroscience and Neural Engineering (CNET) Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.
Kevin BreslinComputational Neuroscience and Neural Engineering (CNET) Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.
KongFatt Wong-LinNeural Systems and Neurotechnology Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.
Jim HarkinComputational Neuroscience and Neural Engineering (CNET) Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.
Bronac FlanaganComputational Neuroscience and Neural Engineering (CNET) Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.
Harm Van ZalingeDepartment of Electrical Engineering and Electronics, University of Liverpool, Liverpool, United Kingdom.
Steve HallDepartment of Electrical Engineering and Electronics, University of Liverpool, Liverpool, United Kingdom.
Mark DallasReading School of Pharmacy, University of Reading, Reading, United Kingdom.
Angela BithellReading School of Pharmacy, University of Reading, Reading, United Kingdom.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Liam McDaidComputational Neuroscience and Neural Engineering (CNET) Research Team, Intelligent Systems Research Centre, Ulster University, Derry, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has recently been proposed using a multi-compartmental mathematical model that negatively fixed charged membrane-associated sites constrain the flow of cations in perisynaptic astroglial processes. This restricted movement of ions between the perisynaptic cradle (PsC), principal astroglial processes and the astrocyte soma gives rise to potassium (K

Indexed as

astrocytic processcalcium microdomainscompartment modelglutamate transportNa+/Ca2+ exchangeperisynaptic cradlesodium dynamics

Identifiers

PMID31133809
PMCPMC6513884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.