Evidence map›Paper›PMID 31133807›Full record

ArticleFrontiers in cellular neuroscience2019

Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1).

Annunziatina Laurino, Elisa Landucci, Lorenzo Cinci, Manuela Gencarelli, Gaetano De Siena, Lorenza Bellusci, Grazia Chiellini, Laura Raimondi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Annunziatina LaurinoDepartments of Neurology, Psychology, Drug Sciences and Child Health, Section of Pharmacology, University of Florence, Florence, Italy.
Elisa LanducciDepartment of Health Sciences, Section of Pharmacology, University of Florence, Florence, Italy.
Lorenzo CinciDepartments of Neurology, Psychology, Drug Sciences and Child Health, Section of Pharmacology, University of Florence, Florence, Italy.
Manuela GencarelliDepartments of Neurology, Psychology, Drug Sciences and Child Health, Section of Pharmacology, University of Florence, Florence, Italy.
Gaetano De SienaDepartment of Health Sciences, Section of Pharmacology, University of Florence, Florence, Italy.
Lorenza BellusciDepartment of Pathology, University of Pisa, Pisa, Italy.
Grazia ChielliniDepartment of Pathology, University of Pisa, Pisa, Italy.
Laura RaimondiDepartments of Neurology, Psychology, Drug Sciences and Child Health, Section of Pharmacology, University of Florence, Florence, Italy.
University of Florence · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-iodothyroacetic acid (TA1), an end metabolite of thyroid hormone, has been shown to produce behavioral effects in mice that are dependent on brain histamine. We now aim to verify whether pharmacologically administered TA1 has brain bioavailability and is able to induce histamine-dependent antidepressant-like behaviors. TA1 brain, liver and plasma levels were measured by LC/MS-MS in male CD1 mice, sacrificed 15 min after receiving a high TA1 dose (330 μgkg

Indexed as

3-iodothyroacetic acidantidepressant effecthistaminemast cellsthyroid hormone

Identifiers

PMID31133807
PMCPMC6517548
OpenAlexW2944765706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.