Evidence map›Paper›PMID 31133798›Full record

ArticleFrontiers in molecular neuroscience2019

No Association of Variants of the NPY-System With Obsessive-Compulsive Disorder in Children and Adolescents.

Maximilian Franke, Annette Conzelmann, Edna Grünblatt, Anna M Werling, Helen Spieles, Christoph Wewetzer, Andreas Warnke, Marcel Romanos, Susanne Walitza, Tobias J Renner

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In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maximilian FrankeDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Annette ConzelmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
Edna GrünblattUniversity Hospital of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
Anna M WerlingUniversity Hospital of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
Helen SpielesDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
Christoph WewetzerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Kliniken der Stadt Köln, Cologne, Germany.
Andreas WarnkeDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Marcel RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Susanne WalitzaUniversity Hospital of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
Tobias J RennerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) causes severe distress and is therefore counted by the World Health Organisation (WHO) as one of the 10 most impairing illnesses. There is evidence for a strong genetic underpinning especially in early onset OCD (eoOCD). Though several genes involved in neurotransmission have been reported as candidates, there is still a need to identify new pathways. In this study, we focussed on genetic variants of the Neuropeptide Y (NPY) system. NPY is one of the most abundant neuropeptides in the human brain with emerging evidence of capacity to modulate stress response, which is of high relevance in OCD. We focussed on tag-SNPs of

Indexed as

anxietychildrenneuropeptideNPYobsessive-compulsive

Identifiers

PMID31133798
PMCPMC6511743

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