Evidence map›Paper›PMID 31133721›Full record

ArticleScientific reports2019

Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-inflammatory Cytokines.

William G Valiant, Mary J Mattapallil, Stephen Higgs, Yan-Jang S Huang, Dana L Vanlandingham, Mark G Lewis, Joseph J Mattapallil

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

William G ValiantF. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Mary J MattapallilNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Stephen HiggsBiosecurity Research Institute, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Yan-Jang S HuangBiosecurity Research Institute, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Dana L VanlandinghamBiosecurity Research Institute, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Mark G LewisBioqual, Rockville, MD, USA.
Joseph J MattapallilF. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, 20814, USA. joseph.mattapallil@usuhs.edu.ORCID http://orcid.org/0000-0002-7412-9507
Kansas State University · USUniformed Services University of the Health Sciences · USBioqual · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consequences of simultaneous infection with Zika (ZIKV) and Dengue (DENV) viruses are poorly understood. Here we show that rhesus macaques experimentally coinfected simultaneously with ZIKV and DENV-2 demonstrated ZIKV or DENV replication without an enhancement of either infection. Coinfection was accompanied by an increase in the proportions of CD14

Indexed as

AnimalsCoinfectionCytokinesDengueDengue VirusDisease Models, AnimalFemaleHumansInflammationMacaca mulattaMaleMonocytesViral LoadVirus ReplicationZika VirusZika Virus InfectionCytokines

Identifiers

PMID31133721
PMCPMC6536518
OpenAlexW2946749496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.