ArticleCell research2019
AIF-regulated oxidative phosphorylation supports lung cancer development.
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Article in Cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
70 citing papers in PubMed, 108 citations in OpenAlex.
- KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.The EMBO journal · 2026Article
- Genomic Profiling Identified a Mutational Signature Related to Female in Nonsmoking Lung Adenocarcinoma.Cancer research and treatment · 2026Article
- Article
- Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy.Acta pharmaceutica Sinica. B · 2026Article
- Review
- AIF, CK5/6, and CK20 in Bladder Urothelial Carcinoma: A Cross-Sectional Immunohistochemical Study of Grade and Stage Associations.Journal of clinical medicine · 2026Article
- Investigating Metabolically Altered Pathways in Small Cell Lung Cancer: From RNA Sequencing Analysis to Seahorse-Based Functional Validation.Methods and protocols · 2026Article
- Metabolic permissiveness: how tissue context shapes cancer.Genes & development · 2026Review
- A prognostic nomogram for overall survival in patients with driver-gene-negative lung adenocarcinoma and its biological basis.Discover oncology · 2026Article
- Preliminary Exploration of Fluvastatin Inhibiting Proliferation, Migration and Invasion of Lung Cancer Cells and Reversing Paclitaxel Resistance: Mechanism Exploration Based on Multi-Omics Analysis.Drug design, development and therapy · 2026Article
- Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer.Oncology research · 2026Review
- Label-free quantitative urinary proteomics for non-invasive biomarker discovery in endometrial cancer.Frontiers in medicine · 2026Article
- Evaluating the potential causal relationship between carnitine-related metabolites and breast cancer: a Mendelian randomization and transcriptomic analysis.Archives of medical science : AMS · 2026Article
- Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes.BMC cancer · 2025Article
- Apoptosis-inducing factor (AIF) at the crossroad of cell survival and cell death: implications for cancer and mitochondrial diseases.Cell communication and signaling : CCS · 2025Review
- Mitochondrial medicine: "from bench to bedside" 3PM-guided concept.The EPMA journal · 2025Article
- Causal effects of immune cells on the efficacy and adverse drug reactions of platinum drugs.Acta biochimica et biophysica Sinica · 2025Article
- Supinoxin blocks small cell lung cancer progression by inhibiting mitochondrial respiration through DDX5.iScience · 2025Article
- Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.In vitro cellular & developmental biology. Animal · 2025Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 12 institutions in 7 countries.
Shuan Rao *Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Laura Mondragón *Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.
Blanka PranjicIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Toshikatsu HanadaIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Gautier StollEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.ORCID http://orcid.org/0000-0002-0862-4139
Thomas KöcherVienna Biocenter Core Facilities, 1030, Vienna, Austria.
Peng ZhangMedical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Alexander JaisDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
Alexander LercherResearch Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0003-3478-5304
Andreas BergthalerResearch Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Daniel SchramekLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada.ORCID http://orcid.org/0000-0001-9977-2104
Katharina HaighVascular Cell Biology Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Valentina SicaEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.
Marion LeducEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.
Nazanine ModjtahediGustave Roussy Cancer Campus, Villejuif, France.
Tsung-Pin PaiIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Masahiro OnjiIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Iris UribesalgoIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Reiko HanadaIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Ivona KozieradzkiIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Rubina KoglgruberIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Shane J CroninIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria.
Zhigang SheDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Franz QuehenbergerInstitute for Medical Informatics, Statistics and Documentation, Medical University Graz, Graz, Austria.ORCID http://orcid.org/0000-0003-0764-9497
Helmut PopperCenter for Diagnostics and Research in Molecular Biomedicine, Pathology Institute for Diagnostics and Research, Medical University Graz, Graz, Austria.ORCID http://orcid.org/0000-0003-4970-1265
Lukas KennerDepartment of Experimental Pathology and Pathology of Laboratory Animals, Medical University Vienna and University of Veterinary Medicine Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-2184-1338
Jody J HaighVascular Cell Biology Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Oliver KeppEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France.ORCID http://orcid.org/0000-0002-6081-9558
Malgorzata RakINSERM, UMR1141, Hopital Robert Debre 48 Boulevard Serurier, 75019, Paris, France.
Kaican CaiDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Guido KroemerEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France. kroemer@orange.fr.
Josef M PenningerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030, Vienna, Austria. josef.penninger@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0002-8194-3777
Institute of Molecular Biotechnology · ATDélégation Paris 5 · FRAustrian Academy of Sciences · ATGhent University · BEInserm · FRMedical University of Graz · ATWuhan University · CNMax Planck Institute for Metabolism Research · DEMount Sinai Hospital · CANanfang Hospital · CNUniversity of Veterinary Medicine Vienna · ATVienna Biocenter · AT
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras
Indexed as
AnimalsApoptosis Inducing FactorCarcinogenesisCarcinoma, Non-Small-Cell LungCell Line, TumorDatasets as TopicDisease ProgressionGlycolysisHumansLung NeoplasmsMiceMice, Inbred C57BLOxidative PhosphorylationAIFM1 protein, humanAIFM1 protein, mouseApoptosis Inducing Factor
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