Evidence map›Paper›PMID 31133693›Full record

ReviewNature medicine2019

Community ecology as a framework for human microbiome research.

Jack A Gilbert, Susan V Lynch

Abstract readReview
In one paragraph

Review in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. The hallmarks of host-microbiome decoupling.Frontiers in microbiology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Bacteriocins fromFrontiers in microbiology · 2026
    Review
  16. Article
  17. Article
  18. Probiotic biogeography and sepsis prevention in the neonatal intestine.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jack A GilbertDepartment of Pediatrics and Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA. gilbertjack@gmail.com.ORCID http://orcid.org/0000-0001-7920-7001
Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. susan.lynch@ucsf.edu.ORCID http://orcid.org/0000-0001-5695-7336

Funding

The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI OWNBY, DENNIS R · 2012 to 2024
$25.7M
Modulating the Impact of Critical Events in Early HIV Infection: Effect of Early ART Initiation and Alcohol UseR01DA040532 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2015 to 2019
$8.0M
Interactions between Environmental Microbiome, Maternal Immunity, Neonatal Epigenome and Respiratory Microbiome Development as Determinants of Asthma In ChildhoodR21AI133765 · NIAID · UNIVERSITY OF ARIZONA · PI LYNCH, SUSAN VERONICA, VERCELLI, DONATA · 2017 to 2018
$439k
Proteomic Predictors of Chronic Kidney Disease in Liver Transplant RecipientsR21AI113916 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEVITSKY, JOSH · 2014 to 2015
$428k
NIAID NIH HHS P01 AI089473NIAID NIH HHS R21 AI113916NIAID NIH HHS R21 AI133765NIDA NIH HHS R01 DA040532
6 · The paper itself

Abstract

The field of human microbiome research has revealed the intimate co-association of humans with diverse communities of microbes in various habitats in the human body, and the necessity of these microbes for the maintenance of human health. Microbial heterogeneity between humans and across spatial and temporal gradients requires multidimensional datasets and a unifying set of theories and statistical tools to analyze the human microbiome and fully realize the potential of this field. Here we consider the utility of community ecology as a framework for the interrogation and interpretation of the human microbiome.

Indexed as

MicrobiotaBiodiversityComputational BiologyEcosystemHost Microbial InteractionsHumansModels, BiologicalResearch

Identifiers

PMID31133693
PMCPMC7410146

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.