Evidence map›Paper›PMID 31133672›Full record

Trial reportScientific reports2019

Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women.

Andrew Teo, Louise M Randall, Mwayiwawo Madanitsa, Victor Mwapasa, Linda Kalilani Phiri, Carole Khairallah, Christelle Buffet, Amalia Karahalios, David L Narum, Feiko O Ter Kuile and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Andrew TeoDepartment of Medicine and Radiology and Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia. andrew.teo@uqconnect.edu.au.
Louise M RandallDepartment of Medicine and Radiology and Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Mwayiwawo MadanitsaCollege of Medicine, University of Malawi, Blantyre, Malawi.
Victor MwapasaCollege of Medicine, University of Malawi, Blantyre, Malawi.ORCID http://orcid.org/0000-0002-2748-8902
Linda Kalilani PhiriCollege of Medicine, University of Malawi, Blantyre, Malawi.
Carole KhairallahDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Christelle BuffetDepartment of Medicine and Radiology and Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Amalia KarahaliosCentre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
David L NarumLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, Maryland, USA.
Feiko O Ter KuileLiverpool School of Tropical Medicine, Liverpool, UK.
Stephen J RogersonDepartment of Medicine and Radiology and Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia. sroger@unimelb.edu.au.ORCID http://orcid.org/0000-0003-4287-1982
The University of Melbourne · AUUniversity of Malawi · MWLiverpool School of Tropical Medicine · GBNational Institute of Allergy and Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermittent preventive therapy against malaria in pregnancy (IPT) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the development and maintenance of malaria antibody immunity were compared. Pregnant Malawian women were randomised to receive IST-DP or IPT-SP. In a nested study, paired enrolment and delivery plasma samples from 681 women were assayed for antibodies against recombinant antigens and for IgG and opsonising antibodies to antigens found on infected erythrocytes (IEs). At delivery, antibody responses did not differ between study arms. Between enrolment and delivery, antibodies to recombinant antigens decreased, whereas antibodies to IEs including opsonising antibodies remained stable. Overall, changes in antibody responses over pregnancy did not differ by treatment arm. Stratifying by gravidity, antibody to schizont extract decreased more in multigravidae receiving IST-DP than IPT-SP. There was minimal impact of treatment arm on the development and maintenance of malaria immunity. While antibodies to recombinant antigens declined between enrolment and delivery, antibodies directed against IEs tended to be more stable, suggesting longer-lasting protection.Clinical trial registration: Pa n African Clinical Trials Registry (PACTR201103000280319) 14/03/2011. URL: http://www.isrctn.com/ISRCTN69800930 .

Indexed as

AntimalarialsArtemisininsMalaria, FalciparumPlasmodium falciparumPregnancy Complications, ParasiticPyrimethamineQuinolinesSulfadoxineAdolescentAdultAntibodies, ProtozoanDrug CombinationsFemaleHumansMalawiMass ScreeningAntibodies, ProtozoanAntimalarialsArtemisininsartenimolDrug Combinationsfanasil, pyrimethamine drug combinationpiperaquinePiperazinesPyrimethamineQuinolinesSulfadoxine

Identifiers

PMID31133672
PMCPMC6536723
OpenAlexW2947814683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.