Evidence map›Paper›PMID 31133559›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.

Julia Terreros-Roncal, Miguel Flor-García, Elena P Moreno-Jiménez, Noemí Pallas-Bazarra, Alberto Rábano, Nirnath Sah, Henriette van Praag, Damiana Giacomini, Alejandro F Schinder, Jesús Ávila and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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  7. KProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Review
  9. Breakdown of the central synapses in C9orf72-linked ALS/FTD.Frontiers in molecular neuroscience · 2022
    Review
  10. Article
  11. Review
  12. CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Julia Terreros-RoncalDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain.
Miguel Flor-GarcíaDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain.
Elena P Moreno-JiménezDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain.
Noemí Pallas-BazarraDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain.ORCID 0000-0002-0175-5080
Alberto RábanoNeuropathology Department, CIEN Foundation, 28031 Madrid, Spain.
Nirnath SahNeuroplasticity and Behavior Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224.
Henriette van PraagNeuroplasticity and Behavior Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0002-5727-434X
Damiana GiacominiLaboratorio de Plasticidad Neuronal, Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), C1405BWE Buenos Aires, Argentina.
Alejandro F SchinderLaboratorio de Plasticidad Neuronal, Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), C1405BWE Buenos Aires, Argentina.ORCID 0000-0003-4863-8348
Jesús ÁvilaDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain.
Maria Llorens-MartínDepartment of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa", CBMSO, CSIC-UAM, 28049 Madrid, Spain, m.llorens@csic.es.ORCID 0000-0001-9129-5198
Biomedical Research Networking Center on Neurodegenerative Diseases · ESConsejo Nacional de Investigaciones Científicas y Técnicas · ARNational Institutes of Health · USFundacion Centro De Investigacion De Enfermedades Neurologicas · ES

Funding

Howard Hughes Medical Institute 55007652
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is characterized by neuronal loss in the frontal and temporal lobes of the brain. Here, we provide the first evidence of striking morphological alterations in dentate granule cells (DGCs) of FTD patients and in a mouse model of the disease, Tau

Indexed as

Disease Models, AnimalAge FactorsAnimalsDentate GyrusFemaleFrontotemporal DementiaHumansMiceMice, Inbred C57BLMice, TransgenicNeurogenesisdentate granule cells (DGCs)DREADDenvironmental enrichmentfrontotemporal dementia (FTD)rabies virusRGB retrovirus

Identifiers

PMID31133559
PMCPMC6636081
OpenAlexW2947135947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.