Evidence map›Paper›PMID 31133558›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Boosting Learning Efficacy with Noninvasive Brain Stimulation in Intact and Brain-Damaged Humans.

Florian Herpich, Michael D Melnick, Sara Agosta, Krystel R Huxlin, Duje Tadin, Lorella Battelli

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05085210 (Visual Restoration of Losses Caused by Cortical Damage), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05085210 narecruitingnot on this mapstarted 2022, after this paper: background citation

Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2022 to 2026Enrolled24ConditionsVisual Field Defect, Peripheral, Stroke, Visual Impairment, HemianopsiaArmstranscranial random noise stimulation (tRNS), Computer Based Visual Training, Sham stimulation, Virtual Reality Based Visual Training
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  12. The Evolving Landscape of Vision Rehabilitation: Current Status and Future Directions.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
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  18. No facilitatory effects of transcranial random noise stimulation on motion processing: A registered report.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Florian HerpichCenter for Neuroscience and Cognitive Systems@UniTn, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy.ORCID 0000-0001-8306-1906
Michael D MelnickDepartment of Brain and Cognitive Sciences, Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14642.
Sara AgostaCenter for Neuroscience and Cognitive Systems@UniTn, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy.ORCID 0000-0002-1004-8265
Krystel R HuxlinDepartment of Brain and Cognitive Sciences, Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14642.
Duje TadinDepartment of Brain and Cognitive Sciences, Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14642.ORCID 0000-0003-1571-5589
Lorella BattelliCenter for Neuroscience and Cognitive Systems@UniTn, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy, Lorella.Battelli@iit.it.ORCID 0000-0001-9981-4028
University of Rochester · USBeth Israel Deaconess Medical Center · USItalian Institute of Technology · ITUniversity of Trento · IT

Funding

VISUAL SCIENCET32EY007125 · NEI · UNIVERSITY OF ROCHESTER · PI Krystel R Huxlin, Duje Tadin · 1990 to 2026
$7.1M
Vision recovery in cortical blindnessR01EY027314 · NEI · UNIVERSITY OF ROCHESTER · PI MARISA CARRASCO, Krystel R Huxlin · 2017 to 2026
$5.3M
Mechanisms of visual learning in cortical blindnessR01EY021209 · NEI · UNIVERSITY OF ROCHESTER · PI HUXLIN, KRYSTEL R · 2011 to 2014
$1.5M
NEI NIH HHS R01 EY021209NEI NIH HHS R01 EY027314NEI NIH HHS T32 EY007125
6 · The paper itself

Abstract

Numerous behavioral studies have shown that visual function can improve with training, although perceptual refinements generally require weeks to months of training to attain. This, along with questions about long-term retention of learning, limits practical and clinical applications of many such paradigms. Here, we show for the first time in female and male human participants that just 10 d of visual training coupled with transcranial random noise stimulation (tRNS) over visual areas causes dramatic improvements in visual motion perception. Relative to control conditions and anodal stimulation, tRNS-enhanced learning was at least twice as fast, and, crucially, it persisted for 6 months after the end of training and stimulation. Notably, tRNS also boosted learning in patients with chronic cortical blindness, leading to recovery of motion processing in the blind field after just 10 d of training, a period too short to elicit enhancements with training alone. In sum, our results reveal a remarkable enhancement of the capacity for long-lasting plastic and restorative changes when a neuromodulatory intervention is coupled with visual training.

Indexed as

Auditory PerceptionLearningAcoustic StimulationAdultBrainFemaleHumansMaleMotion PerceptionNeuronal PlasticityPhotic StimulationStroke RehabilitationTranscranial Direct Current Stimulationcortical plasticitynoninvasive brain stimulationperceptual learningstroke recoverytRNSvisual areas

Identifiers

PMID31133558
PMCPMC6616291
OpenAlexW2905279399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.