ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019
Neurodegenerative Disease Caregivers' 5-HTTLPR Genotype Moderates the Effect of Patients' Empathic Accuracy Deficits on Caregivers' Well-Being.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Empathy and Psychological Outcomes in Informal Caregivers of Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Pooled it
- The role of specific affects in the psychopathology of dementia family caregivers.Emotion (Washington, D.C.) · 2026Article
- Diminished preparatory physiological responses in people with dementia: associations with caregiver health and relationship quality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Empathic Accuracy and Shared Depressive Symptoms in Close Relationships.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Lower activity linkage between caregivers and persons with neurodegenerative diseases is associated with greater caregiver anxiety.Psychophysiology · 2022Article
- Diminished Visual Attention to Emotional Faces Is Associated with Poor Emotional Valence Perception in Frontotemporal Dementia.Dementia and geriatric cognitive disorders · 2022Article
- Poor Disgust Suppression Is Associated with Increased Anxiety in Caregivers of People with Neurodegenerative Disease.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Emotional and Cognitive Empathy in Caregivers of Persons with Neurodegenerative Disease: Relationships with Caregiver Mental Health.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- White Matter Integrity Underlying Depressive Symptoms in Dementia Caregivers.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Article
- Empathic Accuracy in Clinical Populations.Frontiers in psychiatry · 2020Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that a functional polymorphism of the serotonin transporter gene (serotonin-transporter-linked polymorphic region [5-HTTLPR]), which is thought to be associated with differential environmental sensitivity, moderates the association between low levels of empathic accuracy (i.e., ability to recognize emotions in others) in patients with neurodegenerative disease and caregivers' well-being.
methodsParticipants were 54 patients with neurodegenerative disease and their caregivers. Patients' empathic accuracy was measured using a dynamic tracking task in which they continuously rated the emotions of a character in a film; accuracy was determined by comparing patient ratings with those made by an expert panel. Caregivers provided a saliva sample for genotyping. Caregivers' well-being was measured as a latent construct indicated by validated measures of depression, anxiety, and negative affect.
resultsLower levels of patients' empathic accuracy were associated with lower levels of caregivers' well-being. Importantly, caregivers' 5-HTTLPR genotype moderated this association such that lower empathic accuracy in patients predicted lower well-being for caregivers with the short/short genotype (standardized β = 0.66), but not for caregivers with the short/long (standardized β = 0.05) or long/long genotypes (standardized β = -0.21).
conclusionConsistent with previous findings that the short/short variant of 5-HTTLPR is associated with greater sensitivity to environmental influences, caregivers with the short/short variant manifest lower well-being when caring for a patient with low levels of empathic accuracy than caregivers with the other variants. This finding contributes to the authors' understanding of biological factors associated with individual differences in caregiver vulnerability and resilience.
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