ArticleHypertension (Dallas, Tex. : 1979)2019
Antihypertensive Medication Nonpersistence and Low Adherence for Adults <65 Years Initiating Treatment in 2007-2014.
Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Adherence to antihypertensives in the United States: A comparative meta-analysis of 23 million patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.Journal of the American Heart Association · 2022Pooled it
- Effect of a Multicomponent Intervention Delivered on a Web-Based Platform on Hypertension Control: A Cluster Randomized Clinical Trial.JAMA network open · 2022Trial
- Fixed-Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Unused and expired medicines waste in Ireland - an audit of medicines returned to and generated in community pharmacies.Irish journal of medical science · 2026Article
- ADHD and adherence to antihypertensive medication treatment: a multinational cohort study.BMC medicine · 2026Article
- Trends and Predictors of Antihypertensive Medication Adherence in Commercially Insured Adults under 65 (2018-2023).Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Recent Advances in Renal Denervation Therapy and Novel Applications of High-Intensity Focused Ultrasound.Cardiovascular therapeutics · 2025Review
- Impact of blood pressure and medication adherence on clinical outcomes in patients with hypertension.Frontiers in medicine · 2025Article
- Factors associated with medication adherence among young adults with hypertension.Clinical hypertension · 2025Article
- Patterns of use and dose optimization of renin-angiotensin system modulators among chronic heart failure patients with reduced ejection fraction in resource-limited settings: a multicenter cohort study.Therapeutic advances in chronic disease · 2025Article
- Selecting Transfemoral Access or Upper Extremity Access for Renal Denervation Based on Vascular Morphology: Long-term Results.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities.Pediatric nephrology (Berlin, Germany) · 2024Article
- The Association Between Type of Insurance Plan, Out-of-Pocket Cost, and Adherence to Antihypertensive Medications in Medicare Supplement Insurance Enrollees.American journal of hypertension · 2024Article
- Review
- Treatment interruption in hypertensive patients during the COVID-19 pandemic: An interrupted time series analysis using prescription data in Okayama, Japan.Journal of general and family medicine · 2024Article
- Association Between Self-Reported Medication Adherence and Therapeutic Inertia in Hypertension: A Secondary Analysis of SPRINT (Systolic Blood Pressure Intervention Trial).Journal of the American Heart Association · 2024Article
- Antihypertensive and Lipid-Lowering Medication Adherence in Young Adults With Youth-Onset Type 2 Diabetes.JAMA network open · 2023Observational
- Discontinuation of Renin-Angiotensin System Inhibitors During the Early Stage of the COVID-19 Pandemic.American journal of hypertension · 2023Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
Previous evidence suggests modest improvements in antihypertensive medication adherence occurred from 2007 to 2012 among US adults ≥65 years of age. Whether adherence improved over time among adults <65 years of age is unknown. We assessed trends in antihypertensive medication nonpersistence and low adherence among 379 658 commercially insured adults <65 years of age initiating treatment in 2007-2014 using MarketScan claims. Nonpersistence was defined as having no days of medication available to take during the final 90 days of the 365 days following initiation. Among beneficiaries who were persistent to treatment, low adherence was defined by having antihypertensive medication available to take for <80% of the days in the 365 days following initiation (ie, proportion of days covered <80%). In 2007 and 2014, 23.3% and 23.5% of patients were nonpersistent to treatment, respectively, and 42.3% and 40.2% had low adherence, respectively. The relative risks for nonpersistence and low adherence were lower among beneficiaries initiating treatment with an angiotensin-converting enzyme inhibitor (0.95; 95% CI, 0.94-0.97 and 0.97; 95% CI, 0.96-0.98, respectively), angiotensin receptor blocker (0.86; 95% CI, 0.85-0.88 and 0.99; 95% CI, 0.97-1.00, respectively), or multiclass regimen (0.82; 95% CI, 0.80-0.84 and 0.88; 95% CI, 0.86-0.89, respectively), prescribed 90-day versus 30-day prescriptions (0.67; 95% CI, 0.66-0.68 and 0.70; 95% CI, 0.69-0.71, respectively), or who received medications by mail versus at the pharmacy (0.93; 95% CI, 0.90-0.95 and 0.90; 95% CI, 0.88-0.92, respectively). In conclusion, several modifiable factors were associated with lower rates of both antihypertensive medication nonpersistence and low adherence among adults <65 years of age initiating treatment in 2007-2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.