Evidence map›Paper›PMID 31132948›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells.

Fatimah K Khalaf, Prabhatchandra Dube, Andrew L Kleinhenz, Deepak Malhotra, Amira Gohara, Christopher A Drummond, Jiang Tian, Steven T Haller, Zijian Xie, David J Kennedy

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Exploring the Mechanism of NabioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fatimah K KhalafFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Prabhatchandra DubeFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Andrew L KleinhenzFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Deepak MalhotraFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Amira GoharaDepartment of Pathology (A.G.) University of Toledo College of Medicine and Life Sciences, OH.
Christopher A DrummondFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Jiang TianFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Steven T HallerFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
Zijian XieMarshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV (Z.X.).
David J KennedyFrom the Department of Medicine (F.K.K., P.D., A.L.K., D.M., C.A.D., J.T., S.T.H., D.J.K.) University of Toledo College of Medicine and Life Sciences, OH.
University of Toledo · US

Funding

Counter regulatory mechanisms of cardiotonic steroids in cardio-renal syndromeR01HL137004 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KENNEDY, DAVID JOSEPH · 2017 to 2021
$1.9M
Na/K-ATPase Reduction in Renal Disease-Related Cardiac DysfunctionR01HL105649 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TIAN, JIANG · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL105649NHLBI NIH HHS R01 HL137004
6 · The paper itself

Abstract

Cardiotonic steroids (CTSs) are NKA α-1 (Na

Indexed as

Signal TransductionAnimalsBiopsy, NeedleBufanolidesCardiac GlycosidesCells, CulturedChemokinesEpithelial CellsImmunohistochemistryInflammationKidneyMacrophagesMiceRenal Insufficiency, ChronicSensitivity and SpecificitySodium-Potassium-Exchanging ATPaseBufanolidesCardiac GlycosidesChemokinesSodium-Potassium-Exchanging ATPasetelocinobufaginanimalscardiac glycosidesepithelial cellsmacrophagesmice

Identifiers

PMID31132948
PMCPMC6561827
OpenAlexW2946841069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.