Evidence map›Paper›PMID 31132598›Full record

ArticleEpilepsy research2019

Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy.

Aradhya Nigam, Nicholas J Hargus, Bryan S Barker, Matteo Ottolini, James A Hounshell, Edward H Bertram, Edward Perez-Reyes, Manoj K Patel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. T-type CaCell reports · 2023
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aradhya NigamDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Nicholas J HargusDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.
Bryan S BarkerDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.
Matteo OttoliniDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA.
James A HounshellDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.
Edward H BertramNeuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Edward Perez-ReyesNeuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Manoj K PatelDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: mkp5u@virginia.edu.
University of Virginia Health System · US

Funding

Pathogenesis of epilepsy in a SCN8A human mutation mouse modelR01NS103090 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2018 to 2022
$1.8M
Developing a drug-inducible gene therapy for temporal lobe epilepsyR01NS097726 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2016 to 2019
$1.4M
Mechanisms by which T-type calcium channels increase seizure susceptibilityR01NS067456 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2009 to 2010
$770k
Developing a drug-inducible gene therapy for temporal lobe epilepsyR56NS097726 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2023 to 2023
$531k
NINDS NIH HHS R01 NS067456NINDS NIH HHS R01 NS097726NINDS NIH HHS R01 NS103090NINDS NIH HHS R56 NS097726
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is a form of adult epilepsy involving the entorhinal cortex (EC). Layer II neurons of the medial EC (mEC) are spared and become hyperexcitable in TLE. Studies have suggested a role for T-type calcium channels (T-type Ca

Indexed as

Action PotentialsAnimalsBenzamidesCalcium Channel BlockersCalcium Channels, T-TypeEntorhinal CortexEpilepsyMaleNeuronsOrgan Culture TechniquesPiperidinesRatsRats, Sprague-Dawley3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamideBenzamidesCalcium Channel BlockersCalcium Channels, T-TypePiperidinesEntorhinal cortexStellate neuronsTemporal lobe epilepsyT-type calcium channel

Identifiers

PMID31132598
PMCPMC6643284
OpenAlexW2945029473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.