ArticleThe American journal of pathology1987
Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue.
Article in The American journal of pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 131 citations in OpenAlex.
- High frequency of CD74 expression in lymphomas: implications for targeted therapy using a novel anti-CD74-drug conjugate.The journal of pathology. Clinical research · 2019Article
- Phase 1b study of otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR™ therapeutic protein, in combination with rituximab and bendamustine in relapsed indolent lymphoma patients.Investigational new drugs · 2014Article
- Article
- Receptor-directed therapy of T-cell leukemias and lymphomas.Journal of immunotoxicology · 2008Review
- Childhood non-Hodgkin lymphomas in the United Kingdom: findings from the UK Children's Cancer Study Group.Journal of clinical pathology · 1997Article
- B cell lymphoma of the thymus and salivary gland.Journal of clinical pathology · 1996Article
- Sources of DNA for detecting B cell monoclonality using PCR.Journal of clinical pathology · 1994Article
- Intestinal B cell defects in common variable immunodeficiency.Clinical and experimental immunology · 1994Article
- CD40 expression in Hodgkin's disease.The American journal of pathology · 1994Article
- CD43 expression in B cell lymphoma.Journal of clinical pathology · 1992Article
- L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.The American journal of pathology · 1991Article
- Immunoglobulin heavy chain patterns in reactive lymphadenopathy.Journal of clinical pathology · 1991Article
- Detection of immunoglobulin light-chain mRNA in lymphoid tissues using a practical in situ hybridization method.The American journal of pathology · 1990Article
- Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach.The American journal of pathology · 1990Article
- Use of APAAP technique on paraffin wax embedded bone marrow trephines.Journal of clinical pathology · 1989Article
- Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.Journal of clinical pathology · 1989Article
- Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.The American journal of pathology · 1989Article
- A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.The American journal of pathology · 1989Article
- Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
- A comparison between monoclonal antibody MT2 and immunoglobulin staining in the differential diagnosis of follicular lymphoid proliferations in routinely fixed wax-embedded biopsies.The American journal of pathology · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixty-three well characterized B-cell lymphomas, with diagnoses previously established by conventional cryostat immunocytochemistry or limited paraffin immunocytochemistry, were studied. The tumors encompassed most of the Kiel subtypes and included the newly recognized entity, sclerosing mediastinal B-cell lymphoma. by the avidin-biotin peroxidase complex technique, each tumor was stained with a panel of monoclonal and polyclonal antibodies reactive in routinely fixed wax-embedded tissues. The panel included four reagents recognizing probable T-cell and B-cell restricted leukocyte common moieties (UCHL1, MT1, MB1, 4KB5), three antibodies to B-cell-related antigens (KiB3, MB2, LN1), and one to a macrophage-related antigen (Mac411). Other antibodies employed included anti-mu chain, anti-kappa, anti-lambda, and seven antibodies to non-phenotype-associated antigens, including HLA-DR (TAL-1B5, LN3, LN2, MB3), CD15 (C3D-1), and CD30 (BER-H2). Monotypic surface or perinuclear space and cytoplasmic immunoglobulin were detected in 80% of cases. Distinctive immunocytochemical profiles were demonstrable in many tumor categories by means of the panel of antibodies, thus facilitating the differential diagnosis of tumors of similar morphology. These results, together with our work on T-cell lymphoma in paraffin sections, show that accurate phenotypic analysis of lymphoma is now possible in routinely processed tissues.
Indexed as
Identifiers
3113255PMC1899613W217748936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.