Evidence map›Paper›PMID 31132378›Full record

ReviewNeuroscience and biobehavioral reviews2019

Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.

Saranya Sundaram, Rachel L Hughes, Eric Peterson, Eva M Müller-Oehring, Helen M Brontë-Stewart, Kathleen L Poston, Afik Faerman, Chloe Bhowmick, Tilman Schulte

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Guideline
  2. The glymphatic system and Parkinson's disease: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
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  8. Evaluation of glymphatic system activity and lateralization by diffusion tensor imaging in Parkinson's disease with excessive daytime sleepiness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Observational
  15. Article
  16. Article
  17. Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Saranya SundaramDepartment of Psychology, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA; Neuroscience Program, Center for Health Sciences, Bioscience Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA, 94025, USA. Electronic address: ssundaram@paloaltou.edu.
Rachel L HughesDepartment of Psychology, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA. Electronic address: rhughes@paloaltou.edu.
Eric PetersonNeuroscience Program, Center for Health Sciences, Bioscience Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA, 94025, USA. Electronic address: ericpetersongm@gmail.com.
Eva M Müller-OehringNeuroscience Program, Center for Health Sciences, Bioscience Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA, 94025, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA. Electronic address: evamoe@stanford.edu.
Helen M Brontë-StewartDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA; Department of Neurosurgery, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA. Electronic address: hbs@stanford.edu.
Kathleen L PostonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA; Department of Neurosurgery, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA. Electronic address: klposton@stanford.edu.
Afik FaermanDepartment of Psychology, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA. Electronic address: afaerman@paloaltou.edu.
Chloe BhowmickDepartment of Psychology, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA. Electronic address: cbhowmick@paloaltou.edu.
Tilman SchulteDepartment of Psychology, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA; Neuroscience Program, Center for Health Sciences, Bioscience Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA, 94025, USA. Electronic address: tilman.schulte@stanford.edu.
Palo Alto University · USSRI International · USStanford University · US

Funding

TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGINGU01AA017347 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2007 to 2021
$16.0M
Neurodegeneration and Brain Function in Aging with HIV and Parkinson's DiseaseR01AA023165 · NIAAA · SRI INTERNATIONAL · PI SCHULTE, TILMAN · 2014 to 2017
$3.0M
Translational Studies of Brain Circuitry Disrupted by AlcoholismK05AA017168 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2008 to 2017
$2.2M
Basal Ganglia Modulation of Cognitive Systems in Parkinson's diseaseK23NS075097 · NINDS · STANFORD UNIVERSITY · PI POSTON, KATHLEEN LOMBARD · 2011 to 2015
$936k
NIAAA NIH HHS K05 AA017168NIAAA NIH HHS R01 AA023165NIAAA NIH HHS U01 AA017347NINDS NIH HHS K23 NS075097
6 · The paper itself

Abstract

Recent evidence has advanced our understanding of the function of sleep to include removal of neurotoxic protein aggregates via the glymphatic system. However, most research on the glymphatic system utilizes animal models, and the function of waste clearance processes in humans remains unclear. Understanding glymphatic function offers new insight into the development of neurodegenerative diseases that result from toxic protein inclusions, particularly those characterized by neuropathological sleep dysfunction, like Parkinson's disease (PD). In PD, we propose that glymphatic flow may be compromised due to the combined neurotoxic effects of alpha-synuclein protein aggregates and deteriorated dopaminergic neurons that are linked to altered REM sleep, circadian rhythms, and clock gene dysfunction. This review highlights the importance of understanding the functional role of glymphatic system disturbance in neurodegenerative disorders and the subsequent clinical and neuropathological effects on disease progression. Future research initiatives utilizing noninvasive brain imaging methods in human subjects with PD are warranted, as in vivo identification of functional biomarkers in glymphatic system functioning may improve clinical diagnosis and treatment of PD.

Indexed as

alpha-SynucleinCLOCK ProteinsGlymphatic SystemHumansParkinson DiseaseSleep Wake Disordersalpha-SynucleinCLOCK ProteinsAlpha-synucleinClock genesDopamineGlymphatic systemParkinson’s diseaseREM-sleep behavior disorder

Identifiers

PMID31132378
PMCPMC6692229
OpenAlexW2945136852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.