Evidence map›Paper›PMID 31131910›Full record

ArticleJournal of clinical periodontology2019

Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge.

Daniela B Palioto, Livia S Finoti, Denis F Kinane, Manjunatha Benakanakere

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

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  7. Blood Leukocyte DNA Methylation Markers of Periodontal Disease and Risk of Lung Cancer in a Case-Control Study Nested in the CLUE II Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
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  11. CCL5's Role in Periodontal Disease: A Narrative Review.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Daniela B PaliotoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Livia S FinotiDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Denis F KinaneDivision of Periodontology, School of Dental Medicine, University of Geneva, Geneva, Switzerland.
Manjunatha BenakanakereDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-9218-7196
University of Pennsylvania · USUniversidade de São Paulo · BRUniversity of Geneva · CH

Funding

Epigenetics, dysbiosis and inflammation in epithelial cellsR01DE024160 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GRAVES, DANA T · 2015 to 2019
$2.0M
NIDCR NIH HHS R01 DE024160
6 · The paper itself

Abstract

aimThe purpose of this study was to determine inflammatory and epigenetic features following induction of oral and gut dysbiosis in experimental periodontitis in order to examine the interplay between oral and systemic infection. MATERIALS AND

methodsPeriodontitis was induced in 6- to 8-week-old C57BL/6 mice by (a) Ligature placement (Lig group) (oral challenge); (b) P. gingivalis gavage (Pg group) (systemic challenge); and (c) the combination of the two models oral and systemic challenge (Pg + Lig). The duration of the experiment was 60 days, and the animals were then sacrificed for analyses. Alveolar bone loss was assessed, and a multiplex immunoassay was performed. Maxillae and gut tissues were immunostained for DNMT3b (de novo methylation marker), B and T lymphocyte attenuator (BTLA) and IL-18R1 (inflammation markers).

resultsPg and Pg + Lig groups exhibited higher bone loss when compared to Sham. BAFF, VEGF, RANKL, RANTES and IP-10 were significantly higher with Pg gavage. Likewise, DNMT3b was overexpressed in both gut and maxilla after the Pg administration. The same pattern was observed for BTLA and IL-18R1 in gut tissues.

conclusionsThe systemic microbial challenge either alone or in combination with local challenge leads to distinct patterns of inflammatory and epigenetic features when compared to simply locally induced experimental periodontitis.

Indexed as

Alveolar Bone LossPeriodontitisAnimalsDisease Models, AnimalEpigenesis, GeneticMiceMice, Inbred C57BLPorphyromonas gingivalischronic periodontal diseaseepigeneticsexperimental models of periodontitisinflammationsystemic disease

Identifiers

PMID31131910
PMCPMC6641985
OpenAlexW2947780956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.