Evidence map›Paper›PMID 31131879›Full record

ArticleThe Journal of pathology2019

Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.

Yisheng Wang, Michael S Sessine, Yali Zhai, Courtney Tipton, Kevin McCool, Rork Kuick, Denise C Connolly, Eric R Fearon, Kathleen R Cho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Cellular origins of mucinous ovarian carcinoma.The Journal of pathology · 2025
    Review
  4. Article
  5. Review
  6. Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas.Cold Spring Harbor perspectives in medicine · 2023
    Review
  7. Review
  8. Article
  9. Paratubal endosalpingiosis: a case report.International journal of surgery case reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yisheng WangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Michael S SessineDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Yali ZhaiDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Courtney TiptonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kevin McCoolDepartment of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA.
Rork KuickDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Denise C ConnollyFox Chase Cancer Center, Philadelphia, PA, USA.
Eric R FearonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kathleen R ChoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-0500-9998
University of Michigan · USFox Chase Cancer Center · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Credentialing Ovarian Cancer Models in the Context of the Dualistic Pathway ParadigmR01CA196619 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, KATHLEEN R. · 2016 to 2018
$1.4M
Diet, Hormone Replacement Therapy and Breast CancerK07CA096619 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, SHUMIN · 2003 to 2006
$556k
National Cancer Institute at the National Institutes of Health P30CA046592NCI NIH HHS K07 CA096619NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA196619Transgenic Animal Models and Biostatistics, Analytics & Bioinformatics Shared Resources R01CA196619
6 · The paper itself

Abstract

Most high-grade serous carcinomas are thought to arise from Fallopian tube epithelium (FTE), but some likely arise outside of the tube, perhaps from ectopic tubal-type epithelium known as endosalpingiosis. Importantly, the origin of endosalpingiosis is poorly understood. The proximity of the tubal fimbriae to the ovaries has led to the proposal that disruptions in the ovarian surface that occur during ovulation may allow detached FTE to implant in the ovary and form tubal-type glands and cysts. An alternative model suggests that cells present in ectopic locations outside the Müllerian tract retain the capacity for multi-lineage differentiation and can form glands with tubal-type epithelium. We used double transgenic Ovgp1-iCreER

Indexed as

Cell LineageAnimalsBacterial ProteinsCell TrackingEpithelial CellsFallopian Tube NeoplasmsFallopian TubesFemaleGlycoproteinsIntegrasesLuminescent ProteinsMice, TransgenicNeoplasms, Cystic, Mucinous, and SerousOvarian NeoplasmsOvaryPAX8 Transcription FactorBacterial ProteinsCre recombinaseGlycoproteinsGt(ROSA)26Sor non-coding RNA, mouseIntegrasesLuminescent ProteinsOvgp1 protein, mousePax8 protein, mousePAX8 Transcription FactorRNA, UntranslatedTubulinyellow fluorescent protein, BacteriaendosalpingiosisFallopian tubehigh-grade serous carcinomalineage tracingmouse model

Identifiers

PMID31131879
PMCPMC7457448
OpenAlexW2947898460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.