Evidence map›Paper›PMID 31131855›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study.

Kevin L Steiner, Mamun Kabir, Jeffrey W Priest, Biplob Hossain, Carol A Gilchrist, Heather Cook, Jennie Z Ma, Poonum S Korpe, Tahmeed Ahmed, A S G Faruque and 2 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02764918 (Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02764918 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh

TypeobservationalSponsorUniversity of VirginiaRan2024 to 2029Enrolled150ConditionsCryptosporidiosis
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Review
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kevin L SteinerDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.
Mamun Kabiricddr,b, Dhaka, Bangladesh.
Jeffrey W PriestDivision of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Biplob Hossainicddr,b, Dhaka, Bangladesh.
Carol A GilchristDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.
Heather CookDepartment of Statistics, School of Medicine, University of Virginia, Charlottesville.
Jennie Z MaDivision of Biostatistics, Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville.
Poonum S KorpeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Tahmeed Ahmedicddr,b, Dhaka, Bangladesh.
A S G Faruqueicddr,b, Dhaka, Bangladesh.
Rashidul Haqueicddr,b, Dhaka, Bangladesh.
William A PetriDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.
International Centre for Diarrhoeal Disease Research · BDUniversity of Virginia · USJohns Hopkins University · USNational Center for Emerging and Zoonotic Infectious Diseases · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
NIAID NIH HHS R01 AI043596NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI055432
6 · The paper itself

Abstract

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Indexed as

CryptosporidiosisCryptosporidiumAnimalsAntibodies, ProtozoanBangladeshChildHumansImmunoglobulin AProspective StudiesSporozoitesAntibodies, ProtozoanImmunoglobulin ACp23cryptosporidiosisfecalIgAmucosal

Identifiers

PMID31131855
PMCPMC6938969
OpenAlexW2947727240

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.