Evidence map›Paper›PMID 31131410›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Prevalence of Scabies and Impetigo 3 Years After Mass Drug Administration With Ivermectin and Azithromycin.

Michael Marks, Lucia Romani, Oliver Sokana, Lazarus Neko, Relmah Harrington, Titus Nasi, Handan Wand, Margot J Whitfeld, Daniel Engelman, Anthony W Solomon and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Prevalence and determinants of scabies: A global systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2024
    Pooled it
  2. Mass Drug Administration for the Control of Scabies: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Michael MarksClinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Lucia RomaniKirby Institute, University of New South Wales, Sydney.
Oliver SokanaMinistry of Health and Medical Services, Honiara.
Lazarus NekoMinistry of Health and Medical Services, Choiseul.
Relmah HarringtonAtoifi Health Research Group, Malaita, Solomon Islands.
Titus NasiMinistry of Health and Medical Services, Honiara.
Handan WandKirby Institute, University of New South Wales, Sydney.
Margot J WhitfeldSt Vincent's Hospital, University of New South Wales, Sydney.
Daniel EngelmanMurdoch Children's Research Institute, Melbourne, Australia.
Anthony W SolomonClinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
John M KaldorKirby Institute, University of New South Wales, Sydney.
Andrew C SteerKirby Institute, University of New South Wales, Sydney.
UNSW Sydney · AULondon School of Hygiene & Tropical Medicine · GBThe University of Melbourne · AUMinistry of Health · MM

Funding

Wellcome TrustWellcome Trust 098521Wellcome Trust 102807
6 · The paper itself

Abstract

backgroundIvermectin-based mass drug administration has emerged as a promising strategy for the control of scabies and impetigo in settings where the diseases are endemic. Current follow-up data are limited to 12 months for the majority of studies. Longer-term data are vital to inform the sustainability of interventions.

methodsWe conducted a prevalence survey for scabies and impetigo in 10 villages in Choiseul Province of the Solomon Islands 36 months after a single round of ivermectin and azithromycin mass drug coadministration. In the primary analysis, we compared the prevalence of scabies and impetigo at 36 months to the prevalence at baseline.

resultsAt 36 months, the prevalence of scabies was 4.7% (95% confidence interval [CI], 3.6-6.1), which was significantly lower than at baseline (18.7%; relative reduction, 74.9%; 95% CI, 61.5%-87.7%; P < .001). The prevalence of impetigo was 9.6% (95% CI, 8.1%-11.4%), significantly lower than at baseline (24.7%; relative reduction, 61.3%; 95% CI, 38.7%-100%; P < .001). The highest prevalence of scabies was among children aged <5 years (12.5%; adjusted odds ratio, 33.2; 95% CI, 6.6-603.2), and the highest prevalence of impetigo was among children aged 5-9 years (16.4%; adjusted odds ratio, 8.1; 95% CI, 3.6-21.8).

conclusionsThere was a sustained impact of a single round of ivermectin and azithromycin mass drug coadministration on the prevalence of scabies and impetigo 3 years after the intervention. Our data provide further support to adopt this intervention as a central component of global scabies control efforts. CLINICAL TRIALS REGISTRATION: Australian and New Zealand Trials Registry (ACTRN12615001199505).

Indexed as

ImpetigoScabiesAustraliaAzithromycinChildChild, PreschoolHumansIvermectinMass Drug AdministrationMelanesiaNew ZealandPrevalenceAzithromycinIvermectinimpetigoivermectinmass drug administrationneglected tropical diseasesscabies

Identifiers

PMID31131410
PMCPMC7145994
OpenAlexW2946857541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.