ArticleNature metabolism2019
Slc12a8 is a nicotinamide mononucleotide transporter.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 175 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 3 pooled it
15.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
175 citing papers in PubMed, 3 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Domain-specific effects of NADFrontiers in nutrition · 2026Pooled it
- Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.Current diabetes reports · 2024Pooled it
- Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer's Disease: A Systematic Review of Preclinical Studies.Journal of molecular neuroscience : MN · 2021Pooled it
- Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Scientific reports · 2022Trial
- Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.Scientific reports · 2019Trial
- Comparative Evolution of SLC12 Transporters in Tilapias and Salinity-Responsive Expression in Nile Tilapia.International journal of molecular sciences · 2026Article
- Differential NAD + availability may drive asymmetric SIRT7 activity in tumor and immune cells.Molecular biology reports · 2026Review
- Article
- Continuous production of nicotinamide mononucleotide by engineered Escherichia coli: effect of dilution rate and glucose feeding.Bioprocess and biosystems engineering · 2026Article
- Safety of beta-nicotinamide mononucleotide (β-NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC.EFSA journal. European Food Safety Authority · 2026Article
- Stable bioreactor control reveals acidic pH-driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells.Communications biology · 2026Article
- NMN Can Restore Ovarian Reserve in Aged Mice by Upregulating NADReproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration.Aging cell · 2026 · on this mapArticle
- Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis.Aging cell · 2026Article
- SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8Cancer medicine · 2026Article
- Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development.Science advances · 2026Review
- NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis.Nature communications · 2026Article
- Programmed axon degeneration: mechanism, inhibition and therapeutic potential.Nature reviews. Neuroscience · 2026Review
- Polydopamine-Based Antioxidant Countermeasures Against Spaceflight-Induced Neurodegeneration.Small science · 2026Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Alessia GrozioDepartment of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.
Kathryn F MillsDepartment of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.
Jun YoshinoCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Santina BruzzoneDepartment of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, 1 16132 Genova, Italy.
Giovanna SocialiDepartment of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, 1 16132 Genova, Italy.
Kyohei TokizaneDepartment of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.
Hanyue Cecilia LeiDepartment of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.
Richard CunninghamMitchell Cancer Institute, University of South Alabama, Mobile, AL 36606, USA.
Yo SasakiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marie E MigaudMitchell Cancer Institute, University of South Alabama, Mobile, AL 36606, USA.
Shin-Ichiro ImaiDepartment of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.
Washington University in St. Louis · USUniversity of Genoa · ITUSA Mitchell Cancer Institute · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MENAMPT-MEDIATED ADIPO-HYPOTHALAMIC COMMUNICATION FOR NAD+ PRODUCTION AND AGINGR01AG047902 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2014 to 2023
$3.2MTHE ROLE OF DORSOMEDIAL HYPOTHALAMIC NEURONS IN MAMMALIAN AGING AND LONGEVITYR01AG037457 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2011 to 2020
$3.1MMAMMALIAN SIR2 FUNCTION IN PANCREATIC BETA CELLSR01AG024150 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2004 to 2012
$2.7MANIMAL SUPPORT SPACE FOR NEUROSCIENCEC06RR015502 · NCRR · WASHINGTON UNIVERSITY · PI CICERO, THEODORE J · 2000 to 2000
$2.0MBiotechnology and Biological Sciences Research Council BB/N001842/1NCATS NIH HHS UL1 TR002345NCRR NIH HHS C06 RR015502NIA NIH HHS R01 AG024150NIA NIH HHS R01 AG037457NIA NIH HHS R01 AG047902NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341
Abstract
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.