ArticleScience advances2019
Asymmetry in catalysis by
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases.eLife · 2025Article
- Revealing the glutamate switch: Insights into proton translocation in plant HBiophysical journal · 2025Article
- Article
- NaInternational journal of molecular sciences · 2024Article
- Functional and structural asymmetry suggest a unifying principle for catalysis in membrane-bound pyrophosphatases.EMBO reports · 2024Article
- Review
- Exploration of the Catalytic Cycle Dynamics of Vigna Radiata HThe Journal of membrane biology · 2023Article
- mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations.PLoS computational biology · 2022Article
- Pre-steady-state kinetics and solvent isotope effects support the "billiard-type" transport mechanism in NaProtein science : a publication of the Protein Society · 2022Article
- The Mechanism of Energy Coupling in HInternational journal of molecular sciences · 2022Review
- A Lumenal Loop Associated with Catalytic Asymmetry in Plant Vacuolar HInternational journal of molecular sciences · 2021Article
- Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors.ChemMedChem · 2021Article
- Catalytic Asymmetry in Homodimeric HInternational journal of molecular sciences · 2021Article
- A novel high-throughput screen for identifying lipids that stabilise membrane proteins in detergent based solution.PloS one · 2021Article
- Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment.ACS medicinal chemistry letters · 2020Article
- Energy Coupling in Cation-Pumping Pyrophosphatase-Back to Mitchell.Frontiers in plant science · 2020Article
- The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule.Frontiers in molecular biosciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane-bound pyrophosphatases are homodimeric integral membrane proteins that hydrolyze pyrophosphate into orthophosphates, coupled to the active transport of protons or sodium ions across membranes. They are important in the life cycle of bacteria, archaea, plants, and parasitic protists, but no homologous proteins exist in vertebrates, making them a promising drug target. Here, we report the first nonphosphorus allosteric inhibitor of the thermophilic bacterium
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.