Evidence map›Paper›PMID 31131262›Full record

ArticleFrontiers in cellular and infection microbiology2019

Immunomodulation From Moderate Exercise Promotes Control of Experimental Cutaneous Leishmaniasis.

Rodrigo Terra, Pedro J F Alves, Ana K C Lima, Shayane M R Gomes, Luciana S Rodrigues, Verônica P Salerno, Silvia A G Da-Silva, Patricia M L Dutra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. How to Exercise During Coronavirus Quarantine?Caspian journal of internal medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rodrigo TerraDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pedro J F AlvesDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ana K C LimaDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Shayane M R GomesDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana S RodriguesDiscipline of General Pathology, Department of Pathology and Laboratories, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Verônica P SalernoLaboratory of Exercise Biochemistry and Molecular Motors, School of Physical Education and Sports, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Silvia A G Da-SilvaDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Patricia M L DutraDiscipline of Parasitology, Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Universidade do Estado do Rio de Janeiro · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise has been described as an important tool in the prevention and treatment of numerous diseases as it promotes a range of responses and adaptations in several biological systems, including the immune system. Studies on the effect of exercise on the immune system could play a critical role in improving public health. Current literature suggests that moderate intensity exercise can modulate the Th1/Th2 dichotomy directing the immune system to a Th1 cellular immune response, which favors the resolution of infections caused by intracellular microorganisms. Leishmaniasis is a group of diseases presenting a wide spectrum of clinical manifestations that range from self-limiting lesions to visceral injuries whose severity can lead to death. The etiological agents responsible for this group of diseases are protozoa of the genus Leishmania. Infections by the parasite

Indexed as

ImmunomodulationPhysical Conditioning, AnimalAnimalsCytokinesDisease Models, AnimalExercise TherapyLeishmania majorLeishmaniasis, CutaneousMice, Inbred BALB CParasite LoadTh1 CellsTreatment OutcomeCytokinesBalb/ccontrol of infectionexerciseimmune responseleishmaniasis

Identifiers

PMID31131262
PMCPMC6510011
OpenAlexW2943482143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.