Evidence map›Paper›PMID 31131233›Full record

ArticleInternational journal of ophthalmology2019

Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis.

Akash K George, Rubens P Homme, Avisek Majumder, Anwesha Laha, Naira Metreveli, Harpal S Sandhu, Suresh C Tyagi, Mahavir Singh

Open access · goldAbstract read
In one paragraph

Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. PHGDH: a novel therapeutic target in cancer.Experimental & molecular medicine · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Hydrogen Sulfide Actions in the Vasculature.Comprehensive Physiology · 2021
    Article
  12. Review
  13. Epigenetic memory: gene writer, eraser and homocysteine.Molecular and cellular biochemistry · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Akash K GeorgeEye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Rubens P HommeEye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Avisek MajumderDepartment of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.
Anwesha LahaDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Naira MetreveliDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Harpal S SandhuDepartment of Ophthalmology and Visual Sciences; Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Suresh C TyagiDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Mahavir SinghEye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
University of Louisville · US

Funding

FOCUS Data Coordinating CenterU01HL074815 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2003 to 2010
$2.9M
Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque FormationR01NS084823 · NINDS · UNIVERSITY OF LOUISVILLE · PI LOMINADZE, DAVID, TYAGI, SURESH C. · 2013 to 2017
$2.7M
NHLBI NIH HHS U01 HL074815NINDS NIH HHS R01 NS084823
6 · The paper itself

Abstract

aimTo investigate the applications of hydrogen sulfide (H

methodsHeterozygous cystathionine-β-synthase (CBS

resultsCBS deficiency (CBS

conclusionFindings reveal that HHcy-induced glutamate excitotoxicity, oxidative damage, ER-stress and vascular permeability alone or together can compromise ocular health and that GYY4137 could serve as a potential therapeutic agent for treating HHcy induced ocular disorders.

Indexed as

blood-retinal barrier integrityendoplasmic reticulum stressglutamate cytotoxicityinflammationmiceoxidative stress

Identifiers

PMID31131233
PMCPMC6520274
OpenAlexW2947162386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.