ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
On-Demand Coalescence and Splitting of Liquid Marbles and Their Bioapplications.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Composite Liquid Marble Templated Millimetric Capsule With Tunable Rigidity, Porosity, and Thermal Reconfigurability Toward 3D Cell Culture.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Emerging open-channel droplet arrays for biosensing.National science review · 2023Review
- Open millifluidics based on powder-encased channels.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Magnetically Driven Manipulation of Nonmagnetic Liquid Marbles: Billiards with Liquid Marbles.Micromachines · 2022Article
- The gelatin-based liquid marbles for cell cryopreservation.Materials today. Bio · 2022Article
- Optically controlled coalescence and splitting of femtoliter/picoliter droplets for microreactors.RSC advances · 2022Article
- Liquid marbles, floating droplets: preparations, properties, operations and applications.RSC advances · 2022Review
- Fabrication of bioinspired edible liquid marble with phase transition and tunable water barrier property.Bio-design and manufacturing · 2021Article
- Bubble-Assisted Three-Dimensional Ensemble of Nanomotors for Improved Catalytic Performance.iScience · 2019Article
- On-Demand Coalescence and Splitting of Liquid Marbles and Their Bioapplications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coalescence and splitting of liquid marbles (LMs) are critical for the mixture of precise amount precursors and removal of the wastes in the microliter range. Here, the coalescence and splitting of LMs are realized by a simple gravity-driven impact method and the two processes are systematically investigated to obtain the optimal parameters. The formation, coalescence, and splitting of LMs can be realized on-demand with a designed channel box. By selecting the functional channels on the device, gravity-based fusion and splitting of LMs are performed to mix medium/drugs and remove spent culture medium in a precise manner, thus ensuring that the microenvironment of the cells is maintained under optimal conditions. The LM-based 3D stem cell spheroids are demonstrated to possess an approximately threefold of cell viability compared with the conventional spheroid obtained from nonadhesive plates. Delivery of the cell spheroid to a hydrophilic surface results in the in situ respreading of cells and gradual formation of typical 2D cell morphology, which offers the possibility for such spheroid-based stem cell delivery in regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.