Evidence map›Paper›PMID 31131042›Full record

ArticleDiabetology & metabolic syndrome2019

Therapeutic effects of stem cells from human exfoliated deciduous teeth on diabetic peripheral neuropathy.

Jing Xie, Nanquan Rao, Yue Zhai, Jingzhi Li, Yuming Zhao, Lihong Ge, Yuanyuan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing Xie1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Nanquan Rao1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Yue Zhai1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Jingzhi Li1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Yuming Zhao1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Lihong Ge1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Yuanyuan Wang1Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081 China.
Peking University · CNShenzhen Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the therapeutic potential of stem cells from human exfoliated deciduous teeth (SHED) for diabetic peripheral neuropathy.

methodsThe biological characteristics of SHED were identified by flow cytometric study and evaluation of differentiation potential. Using high-fat feeding, diabetes was induced in GK rats, and SHED were transplanted into the caudal veins of these rats. Immunohistochemical analysis was used to compare the capillary to muscle fiber ratio and intra-epidermal nerve fiber density between SHED- and saline-treated diabetic rats. Further, the expressions of angiogenesis-related and neurotrophic factors were quantified by real-time PCR and western blot.

resultsSHED had a capacity of multiple differentiation and shared typical characteristics of mesenchymal stem cells. SHED transplantation relieved diabetic neuropathic pain, enabled functional recovery of the peripheral nerves, and increased the capillary to muscle fiber ratio and intra-epidermal nerve fiber density compared to the saline group and normal controls. Real-time PCR results showed that the expressions of CD31, vWF, bFGF, NGF, and NT-3 in the skeletal muscles were higher in the SHED group than in the saline groups. Western blot results indicated that the levels of the CD31 and NGF proteins were higher in the SHED transplantation group than the saline group.

conclusionSHED transplantation ameliorated diabetic peripheral neuropathy in diabetic GK rats. Thus, systemic application of SHED could be a novel strategy for the treatment of diabetic peripheral neuropathy.

Indexed as

Diabetic peripheral neuropathyGoto-Kakizaki ratsStem cells from human exfoliated deciduous teethStem cell therapy

Identifiers

PMID31131042
PMCPMC6525430
OpenAlexW2947108084

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.