Evidence map›Paper›PMID 31131037›Full record

ReviewEuropean cardiology2019

The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives.

Sotirios Tsalamandris, Alexios S Antonopoulos, Evangelos Oikonomou, George-Aggelos Papamikroulis, Georgia Vogiatzi, Spyridon Papaioannou, Spyros Deftereos, Dimitris Tousoulis

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06195566 (Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management), which is not on this map. Cited by 741 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
741citing papers in PubMed, 6 pooled it
87.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06195566 completednot on this mapstarted 2024, after this paper: background citation

Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management

TypeobservationalSponsorJelizaveta SokolovskaRan2024 to 2025Enrolled77ConditionsPrediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
3 · Its place in the literature

Who cites it

741 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,353 citations in OpenAlex.

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  4. Cross-Study Meta-Analysis of Blood Transcriptomes in Type 2 Diabetes.International journal of molecular sciences · 2025
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681 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sotirios TsalamandrisFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Alexios S AntonopoulosFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Evangelos OikonomouFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
George-Aggelos PapamikroulisFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Georgia VogiatziFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Spyridon PapaioannouFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Spyros DeftereosFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
Dimitris TousoulisFirst Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is a complex metabolic disorder affecting the glucose status of the human body. Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical relationship between diabetes and atherosclerotic cardiovascular disease is well established. This makes therapeutic approaches that simultaneously target diabetes and atherosclerotic disease an attractive area for research. The majority of people with diabetes fall into two broad pathogenetic categories, type 1 or type 2 diabetes. The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several clinical trials to have been completed while more are in development. The emerging role of inflammation in both type 1 and type 2 diabetes (T1D and T1D) pathophysiology and associated metabolic disorders, has generated increasing interest in targeting inflammation to improve prevention and control of the disease. After an extensive review of the possible mechanisms that drive the metabolic pattern in T1D and T2D and the inflammatory pathways that are involved, it becomes ever clearer that future research should focus on a model of combined suppression for various inflammatory response pathways.

Indexed as

adipose tissueanti-inflammatory treatmentdiabetesInflammationmetabolic disordersobesity

Identifiers

PMID31131037
PMCPMC6523054
OpenAlexW2944544314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.